The stability study of superparamagnetic iron oxide nanoparticles modified by dextran

LI Meng-ya et al

doi:10.13406/j.cnki.cyxb.2010.03.047

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The stability study of superparamagnetic iron oxide nanoparticles modified by dextran

更新时间：2024-01-17

- The stability study of superparamagnetic iron oxide nanoparticles modified by dextran
- Journal of Chongqing Medical University Vol. 35, Issue 3, Pages: 396-399(2010)
- 作者机构：
  
  重庆医科大学附属第一医院放射科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.03.047
  CLC： R943
- Published：2010，
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[1]李梦雅,文明,李少林.葡聚糖修饰的纳米级超顺磁性氧化铁稳定性检测[J].重庆医科大学学报,2010,35(03):396-399.

LI Meng-ya et al. The stability study of superparamagnetic iron oxide nanoparticles modified by dextran. [J]. Journal of Chongqing Medical University 35(3):396-399(2010)
[1]李梦雅,文明,李少林.葡聚糖修饰的纳米级超顺磁性氧化铁稳定性检测[J].重庆医科大学学报,2010,35(03):396-399. DOI： 10.13406/j.cnki.cyxb.2010.03.047.

LI Meng-ya et al. The stability study of superparamagnetic iron oxide nanoparticles modified by dextran. [J]. Journal of Chongqing Medical University 35(3):396-399(2010) DOI： 10.13406/j.cnki.cyxb.2010.03.047.

摘要

目的:研究共沉淀法制备葡聚糖修饰的纳米级超顺磁性氧化铁的稳定性。方法:参照一般注射试剂的基本要求

对采用共沉淀法制备葡聚糖修饰的纳米级超顺磁性氧化铁液体

分别进行强化实验和长期实验

观察或测定样品的性状、pH值、铁浓度、粒径、饱和磁化强度及T2磁豫率等参数。结果:与实验前所检测的数据比较

实验后各项数据无统计学差异。结论:葡聚糖修饰的纳米级超顺磁性氧化铁稳定性好

为进一步将其作为磁共振成像对比剂及靶向基因载体研究奠定了基础。

Abstract

Objective:To study the stability of Superparamagnetic iron oxide(SPIO) nanoparticles modified by dextran prepared by coprecipitation.Methods:To evaluate its stability through compared the characteristic parameters which contained the character

iron content

size

saturated magnetization and T2 relaxivity before and after the strengthen experimentation and the long-term experimentation.All that was carried according to the basic request of injection requirements.Results:The above characteristic parameters had no statistic differences between before experimentation and after experimentation.Conclusion:The research showed that SPIO made by coprecipitation had good stability

can be further used as the contrast media of magnetic resonance imaging and target gene carrier.

关键词

超顺磁性氧化铁纳米粒子稳定性

Keywords

superparamagnetic iron oxideNanoparticlesstability

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