Detection of insulin-like growth factor-1 can predict vascular disease in diabetic lower limb

JIANG Gui-ming

doi:10.13406/j.cnki.cyxb.2010.03.016

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Detection of insulin-like growth factor-1 can predict vascular disease in diabetic lower limb

更新时间：2024-01-17

- Detection of insulin-like growth factor-1 can predict vascular disease in diabetic lower limb
- Journal of Chongqing Medical University Vol. 35, Issue 3, Pages: 430-432(2010)
- 作者机构：
  
  广西省兴安县中医院内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.03.016
  CLC： R587.2
- Published：2010，
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[1]蒋桂明.胰岛素样生长因子-1检测对糖尿病下肢血管病变的预测价值[J].重庆医科大学学报,2010,35(03):430-432.

JIANG Gui-ming. Detection of insulin-like growth factor-1 can predict vascular disease in diabetic lower limb. [J]. Journal of Chongqing Medical University 35(3):430-432(2010)
[1]蒋桂明.胰岛素样生长因子-1检测对糖尿病下肢血管病变的预测价值[J].重庆医科大学学报,2010,35(03):430-432. DOI： 10.13406/j.cnki.cyxb.2010.03.016.

JIANG Gui-ming. Detection of insulin-like growth factor-1 can predict vascular disease in diabetic lower limb. [J]. Journal of Chongqing Medical University 35(3):430-432(2010) DOI： 10.13406/j.cnki.cyxb.2010.03.016.

摘要

目的:探讨胰岛素样生长因子-1（Insulin-like growth factor-1

IGF-1）在糖尿病下肢血管病变中的预测价值。方法:对138例2型糖尿病患者进行下肢血管病变的检查

以DSA结果为下肢血管病变诊断的金标准。ELISA法测IGF-I水平

应用ROC及评价预测价值

以Youden指数确定诊断界点。结果:随着下肢血管狭窄程度的增高

患者血清IGF-1水平逐渐增高（P<0.05）。IGF-1水平和ABI（r=0.761

P=0.014）、彩超（r=0.796

P=0.021）及DSA检查（r=0.856

P=0.008）的血管狭窄程度均呈正相关。IGF-1对DM下肢血管病变具有很好的预测价值（AUC=0.734

P=0.001）

95%的CI为0.621～0.846。诊断界点为180.0ng/mL时

其诊断效能最高。结论:IGF-1对糖尿病下肢血管病变中有较好的预测价值。

Abstract

Objective:To investigate the value of insulin-like growth factor-1(IGF-1) in diabetes for predicting lower limb vascular disease.Methods:138 patients with type 2 diabetes were checked with lower extremity vascular disease in which DSA results as gold diagnostic standard.ELISA were used to measure IGF-I levels.The predictive value was evaluated by ROC and Youden index for cut-off point.Results:With the extent of lower extremity vascular stenosis increased

serum levels of IGF-1 was gradually increased(P <0.05).IGF-1 levels was positively correlated with ABI(r=0.761

P=0.014) for the degree of vascular stenosis as well as color Doppler ultrasound(r =0.796

P=0.021)

and DSA examination(r= 0.856

P=0.008).IGF-1 has a very good predictive value for DM lower extremity vascular disease(AUC= 0.734

P =0.001)

95% of the CI

0.621～0.846.The cut-off point was 180.0 ng /mL.Conclusion:IGF-1 has a good predictive value for diabetic lower extremity vascular disease.

关键词

糖尿病下肢血管病变胰岛素样生长因子-1诊断

Keywords

diabetes mellitusLower limb vascular diseaseinsulin-like growth factor-1diagnosis

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