Detecting IL-2 and IL-10 to predicate treatment outcome for Graves disease

LI Chun-bei

doi:10.13406/j.cnki.cyxb.2010.03.015

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Detecting IL-2 and IL-10 to predicate treatment outcome for Graves disease

更新时间：2024-01-17

- Detecting IL-2 and IL-10 to predicate treatment outcome for Graves disease
- Journal of Chongqing Medical University Vol. 35, Issue 3, Pages: 412-414(2010)
- 作者机构：
  
  四川攀枝花市中心医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.03.015
  CLC： R581.1
- Published：2010，
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[1]李春北.IL-2与IL-10浓度变化对Graves病治疗效果的预测[J].重庆医科大学学报,2010,35(03):412-414.

LI Chun-bei. Detecting IL-2 and IL-10 to predicate treatment outcome for Graves disease. [J]. Journal of Chongqing Medical University 35(3):412-414(2010)
[1]李春北.IL-2与IL-10浓度变化对Graves病治疗效果的预测[J].重庆医科大学学报,2010,35(03):412-414. DOI： 10.13406/j.cnki.cyxb.2010.03.015.

LI Chun-bei. Detecting IL-2 and IL-10 to predicate treatment outcome for Graves disease. [J]. Journal of Chongqing Medical University 35(3):412-414(2010) DOI： 10.13406/j.cnki.cyxb.2010.03.015.

摘要

目的:探讨IL-2和IL-10变化对Graves病（Graves disease

GD）治疗转归的影响。方法:以2007年1月至2008年12月入我院治疗的GD患者72例

分别于治疗前及治疗后5月检测IL-2和IL-10及甲状腺素水平

评价IL-2和IL-10水平与治疗转归的关系。结果:72例GD患者甲亢未控制者21例

甲亢控制者35例

早发性甲减者16例。IL-2在甲亢未控制者水平最高

甲亢控制者次之

而早发性甲减者最低（P<0.05）;IL-10水平则成反变趋势（P<0.05）。治疗后甲亢未控制者治疗后IL-2升高

甲亢控制者IL-2基本不变

而早发性甲减者IL-2下降（P<0.05）;IL-10水平也成反变趋势（P<0.05）。IL-2/IL-10水平在甲亢控制者水平最高

甲亢控制者次之

而早发性甲减者最低（P<0.05）;而治疗前后IL-2/IL-10水平基本相当（P>0.05）。结论:IL-2/IL-10比值越高甲亢越难控制

比值越低越易产生甲减;IL-2/IL-10是较好的GD治疗效果预测指标。

Abstract

Objective:To investigate the IL-2 and IL-10 changes impact of treatment outcome in Graves disease(GD).Methods:From January 2007 to December 2008

72 cases of patients with GD in our hospital were detected IL-2 and IL-10 and thyroid hormone levels before and after treatment respectively

the relationship between the IL-2 and IL-10 level with prognosis was evaluated.Results:There are 21 cases of GD in patients with uncontrolled hyperthyroidism

35 cases with hyperthyroidism control

16 cases of early-onset hypothyroidism.The level of IL-2 in uncontrolled hyperthyroidism were the highest

followed by hyperthyroidism control

and in early-onset hypothyroidism were the lowest(P <0.05);IL-10 levels into the trend of anti-change(P<0.05).After treatment

IL-2 increased in uncontrolled hyperthyroidism

in hyperthyroidism control

IL-2 was essentially the same

and in early-onset hypothyroidism

IL-2 decreased(P <0.05);IL-10 levels into the anti-change(P <0.05).IL-2/IL-10 was highest level in uncontrolled hyperthyroidism

followed by hyperthyroidism control

and in early-onset hypothyroidism was the lowest(P<0.05);and the level of IL-2/IL-10 was the same before and after treatment(P>0.05).Conclusion:The higher IL-2/IL-10 ratio shows more difficult for control hyperthyroidism

the lower IL-2/IL-10 ratio shows more easy to produce hypothyroidism;IL-2/IL-10 is a good predictor for GD treatment outcome.

关键词

Graves病细胞因子IL-2IL-10疗效

Keywords

Graves diseasecytokinesIL-2IL-10Treatment outcome

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Department of Emergency and Intensive Care Unit,The First Affiliated Hospital of Chongqing Medical University

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