Relationship between matrix metalloproteinases-2(MMP-2) and atrial fibrillation

LI Shu-min; et al

doi:10.13406/j.cnki.cyxb.2010.03.010

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Relationship between matrix metalloproteinases-2(MMP-2) and atrial fibrillation

更新时间：2024-01-17

- Relationship between matrix metalloproteinases-2(MMP-2) and atrial fibrillation
- Journal of Chongqing Medical University Vol. 35, Issue 3, Pages: 439-441(2010)
- 作者机构：
  
  1. 佳木斯大学临床医学院医学检验系
  2. 鸡西矿业总医院医疗集团内二科
  3. 重庆医科大学现代教育技术中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.03.010
  CLC： R541.75
- Published：2010，
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[1]李树民,孙艳霞,冉华全,孙玉鸿,王泽宇.基质金属蛋白酶-2及其抑制因子与心房颤动的相关性研究[J].重庆医科大学学报,2010,35(03):439-441.

LI Shu-min, et al. Relationship between matrix metalloproteinases-2(MMP-2) and atrial fibrillation. [J]. Journal of Chongqing Medical University 35(3):439-441(2010)
[1]李树民,孙艳霞,冉华全,孙玉鸿,王泽宇.基质金属蛋白酶-2及其抑制因子与心房颤动的相关性研究[J].重庆医科大学学报,2010,35(03):439-441. DOI： 10.13406/j.cnki.cyxb.2010.03.010.

LI Shu-min, et al. Relationship between matrix metalloproteinases-2(MMP-2) and atrial fibrillation. [J]. Journal of Chongqing Medical University 35(3):439-441(2010) DOI： 10.13406/j.cnki.cyxb.2010.03.010.

摘要

目的:探讨血清中基质金属蛋白酶-2（Matrix Metalloproteinases-2

MMP-2）及其抑制因子（Tissue inhibitor of metallop roteinase 2

TIMP-2）与心房颤动（房颤）患者心功能、左房内径的关系。方法:选择49例持续性（持续时间大于7d）房颤患者和47例窦性心律患者

分为房颤组和窦律组。采用ELISA测定两组血清MMP-2、TIMP-2水平

并用彩超测量两组患者左房内径的大小。结果:（1）房颤组血清MMP-2水平明显高于窦律组（P<0.05）

且与左房内径大小呈直线正相关关系（r=0.345

P<0.05）。TIMP-2水平在房颤组与窦律组间无差异（P>0.05）。（2）房颤组患者左房内径水平明显高于窦律组（P<0.01）。结论:房颤组患者的MMP-2水平较窦律组高

且随心功能恶化而升高

可能是导致持续性房颤患者左心房内径扩大的原因之一。

Abstract

Objiective:To investigate the relationship between matrix metalloproteinases-2(MMP-2) and atrial fibrillation

also to investigate the relationship between MMP-2

cardiac function and left atria diameter of patients with atrial fibrillation.Methods:49 patients with persistent atrial fibrillation were included in the atrial fibrillation groups

and 47 patients with sinus rhythm were selected in the control group

the serum concentration of MMP-2 and TIMP-2 were measured with ELISA.The size of left atria diameter were detected with Doppler Ultrasonic cardiogram.Results:(1) The level of MMP-2 in atrial fibrillation group was significantly higher than that in control group(P<0.05)

there was a positive correlation between left atria diameter and serum MMP-2 levels in the atrial fibrillation group(r=0.345

P<0.05).The level of the serum TIMP-2 showed no difference between the atrial fibrillation group and the control group(P>0.05).(2) The size of left atria diameter in atrial fibrillation group was significant higher than that in the control group(P<0.01).Conclusions:The levels of serum MMP-2 increased in patients with persistent atrial fibrillation

both rose with severity of chronic heart failure.Rising of MMP-2 levels is one of the reason that left atria enlarged in persistent atrial fibrillation.

关键词

心房颤动基质金属蛋白酶

Keywords

atrial fibrillationmatrix metalloproteinase

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