Objective:To discuss the inhibitory effect of ultrasound fitted irrad-iation paclitaxel-carrying liposome microbubbles(PLM) agent on nude micetran-splanted human ovarian carcinoma and its possible mechanism of action.Methods:We established nude mice transplanted SKOV3 human ovarian carcinoma.Then mice were randomly divided into 4 groups(5 mice in each group).Each group was treated in a different way.The rate of tumor inhibition was calculatedafter sacrificing the animals at the end of experiment.The nuclear associated an-tigen Ki-67 was measured immunohistochemically and analyzed through comput-er.Tumor tissues were observed under the transmission electrion microscope(TEM).Results:Compared with control

the growth of tumor in PLM combined ultr-asound group and paclixtaxel chemotherapy group was slow and the inhibitory effect of tumor was significant(P<0.01).The Ki67 expression were all decreased(P<0.01).But the former which inhibitory effect of tumor was much more signi-ficant(P<0.01).Apoptosisbodies were observed under transmission electron micr-oscope and the PLM combined ultrasound group was stronger than other groups.Conclusion:Ultrasound destructing PLM agent has good therapeutic effect in the treatment of nude mice transplanted human ovarian carcinoma.The mechanism of action may be its antiangiogenetic effect

interrupting

inhibiting proliferation and inducing apoptosis.