The expression and the clinical significance of Id<sub>1</sub> and Id<sub>3</sub> in human non-small cell lung cancer

XU-Jun; et al

doi:10.13406/j.cnki.cyxb.2010.02.036

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The expression and the clinical significance of Id₁ and Id₃ in human non-small cell lung cancer

更新时间：2024-01-17

- The expression and the clinical significance of Id₁ and Id₃ in human non-small cell lung cancer
- Journal of Chongqing Medical University Vol. 35, Issue 2, Pages: 213-216(2010)
- 作者机构：
  
  重庆医科大学附属第一医院胸心外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.02.036
  CLC： R734.2
- Published：2010，
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[1]徐俊,秦治明.Id_1与Id_3在非小细胞肺癌中的表达及临床意义[J].重庆医科大学学报,2010,35(02):213-216.

XU-Jun, et al. The expression and the clinical significance of Id₁ and Id₃ in human non-small cell lung cancer. [J]. Journal of Chongqing Medical University 35(2):213-216(2010)
[1]徐俊,秦治明.Id_1与Id_3在非小细胞肺癌中的表达及临床意义[J].重庆医科大学学报,2010,35(02):213-216. DOI： 10.13406/j.cnki.cyxb.2010.02.036.

XU-Jun, et al. The expression and the clinical significance of Id₁ and Id₃ in human non-small cell lung cancer. [J]. Journal of Chongqing Medical University 35(2):213-216(2010) DOI： 10.13406/j.cnki.cyxb.2010.02.036.

摘要

目的:探索分化抑制因子（Inhibitors of differentiation

Id）Id

和Id

在非小细胞肺癌（Non-small cell lung cancer

NSCLC）中的表达及临床意义。方法:采用免疫组化S-P法检测60例NSCLC、8例炎性假瘤、10例肺结核、12例正常肺组织中Id

和Id

的表达情况。结果:在人NSCLC组织中

和Id

均过度表达

与正常肺组织及良性病变组织（结核和炎性假瘤）比较差异具有显著性（P

0.01）;在不同年龄、性别及病理类型中表达的差异无统计学意义（P

0.05）;在肿瘤有淋巴结转移组中表达的明显高于无淋巴结转移组

统计分析差异具有显著性（P

0.05）。结论:Id

、Id

蛋白与NSCLC的发生发展及淋巴结转移有关

可能作为NSCLC诊断及判断预后的重要标志物。

Abstract

Objective:To study the expression of Id

and Id

in human non-small cell lung cancer（NSCLC）

and to analyze its potential clinical significance.Methods:Id

and Id

were detected by immunohistochemical staining technique in paraffine-embedded specimens of 60 NSCLC cases

18 benign disease cases including 10 tuberculosis and 8 inflammatory pseudotumor（IPT）

and 12 normal lung cases

and analyzed by the lung cancer clinicopathologic characteristics.Results:There were no Id

or Id

expression in normal lung tissue

and negative to weak expression of those in benign disease tissues.In contrast

the expression of Id1 and Id

was obviously upregulated in NSCLC

which was significantly higher than that in benign disease（P

0.01）.Furthermore

the over expression of Id

and Id

was significantly correlated with lymph node metastasis and was not correlated with pathological type

the different age or the different gender of the patients.Conclusion:In NSCLC

and Id

protein are overexpressed and their expression are positive correlated with lymph node metastasis.It suggested that Id

and Id

are associated with tumorigenesis

invasion and metastasis in NSCLC.Id

and Id

might be used as new markers of NSCLC for diagnosis and prognosis.

关键词

Id1和Id3蛋白非小细胞肺癌免疫组化

Keywords

Id1 and Id3 proteinNSCLCimmunohistochemistry

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⁰

The expression and the clinical significance of Id1 and Id3 in human non-small cell lung cancer

DOI：10.13406/j.cnki.cyxb.2010.02.036

摘要

Abstract

关键词

Keywords

references

The expression and the clinical significance of Id₁ and Id₃ in human non-small cell lung cancer