Allergen sensitization changes in Children with asthma often treatment with house dust mite specific immunotherapy

WEI Jin-feng; et al

doi:10.13406/j.cnki.cyxb.2010.02.026

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Allergen sensitization changes in Children with asthma often treatment with house dust mite specific immunotherapy

更新时间：2024-01-17

- Allergen sensitization changes in Children with asthma often treatment with house dust mite specific immunotherapy
- Journal of Chongqing Medical University Vol. 35, Issue 2, Pages: 313-316(2010)
- 作者机构：
  
  重庆医科大学附属儿童医院呼吸科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.02.026
  CLC： R725.6
- Published：2010，
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[1]魏金凤,刘恩梅,陈坤华,黄英,蒋永慧.尘螨特异性免疫治疗前后哮喘患儿过敏原变化趋势[J].重庆医科大学学报,2010,35(02):313-316.

WEI Jin-feng, et al. Allergen sensitization changes in Children with asthma often treatment with house dust mite specific immunotherapy. [J]. Journal of Chongqing Medical University 35(2):313-316(2010)
[1]魏金凤,刘恩梅,陈坤华,黄英,蒋永慧.尘螨特异性免疫治疗前后哮喘患儿过敏原变化趋势[J].重庆医科大学学报,2010,35(02):313-316. DOI： 10.13406/j.cnki.cyxb.2010.02.026.

WEI Jin-feng, et al. Allergen sensitization changes in Children with asthma often treatment with house dust mite specific immunotherapy. [J]. Journal of Chongqing Medical University 35(2):313-316(2010) DOI： 10.13406/j.cnki.cyxb.2010.02.026.

摘要

目的:探讨经标准化尘螨特异性免疫治疗（Specific immunotherapy

SIT）前后

哮喘患儿吸入性过敏原的变化趋势。方法:收集2005年6月～2007年3月140例在重庆医科大学附属儿童医院进行标准化尘螨特异性免疫治疗哮喘患儿的资料

对其治疗前后分别做尘螨、花粉、霉菌

蟑螂等13种常见的吸入性过敏原的皮肤点刺试验

并对其变化进行统计学分析。结果:皮肤点刺试验显示哮喘患儿中3种螨同时为阳性72.86%（103/140）

螨合并其他过敏原阳性62.85%（88/140）;93例患儿经治疗半年后

除猫毛和花粉外

3种螨虫、狗毛、蟑螂、霉菌的过敏原直径较治疗前有显著下降（P<0.0001）;78例患儿经治疗1年后

各过敏原的直径均有显著下降（蟑螂和花粉P<0.005

余P<0.000 1）;尘螨合并其他过敏原阳性的患儿经半年或1年治疗后

其他过敏原全部转阴率均>70%;标准化尘螨特异性免疫治疗半年和1年后未发生新发过敏原的比例分别为84.95%（79/93）和87.18%（68/78）。结论:标准化尘螨特异性免疫治疗不仅对尘螨而且对其他过敏原过敏的患儿均有显著疗效

其疗效与时间剂量呈相关性

提示通过单一脱敏治疗可以达到对其他过敏原的理想治疗;同时标准化特异性免疫治疗可能对新发过敏原有一定的阳止作用。

Abstract

Objective:This study was aimed to analyze the allergen sensitization changes of Skin Prick Tests(SPT)in Children who met the following criteria:diagnosed with asthma

sensitized to House Dust Mite(HDM)or HDM in combination with other allergens and accepting standard HDM specific immunotherapy(SIT).Methods:140 patients were recruited in this study.SPT was performed with a panel of allergens including HDM

cockroach

cat hair

dog hair

moulds

and pollens and we compared the SPT allergen sensitization results of pre-treatment and post-treatment.Results:Of the all 140 patients

72.86%(103/140)was HDM-monosensitized

62.85%was sensitized to HDM in combination with other allergens.SPT was reperformed in 93 of these patients which were treated by SIT for 6 months

and compared with the pre-SIT results

the SPT wheal diameters of all allergens were significantly decreased(P<0.000 1)

except cat hair (P>0.05)and pollen(P>0.05)

and in 78 patients with 12-month SIT treatment

the SPT wheal diameters of all allergens were significantly decreased(p<0.000 1)

cockroach(P<0.005)and pollen(P<0.005).After 6-month or 12-month standard HDM SIT treatment

more than 70%of theses children sensitized to HDM in combination with other allergens were desensitized to the other allergens. After 6-month or 12-month of HDM SIT treatment

there were 84.95%and 87.18%patients showing no new sensitization.Conclusion:SPT allergen sensitization results could be well improved by the treatment of standard HDM SIT

the effectiveness of which is time-and dose-dependent.It is possible that children with multi-allergen sensitization could be desensitisized by a single allergen extraction SIT:HDM SIT has the potential to prevent the onset of new sensitizations in children with rhinitis and/or asthma.

关键词

儿童哮喘尘螨免疫治疗新发致敏作用

Keywords

childrenasthmaHouse dust miteSpecific immunotherapyNew sensitization

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Department of Respiratory,the Children’s Hospital,Chongqing Medical University

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