Effects of metformin and rosiglitazone in the treatment of polycystic ovarian syndrome with insulin resistance

SUN Yu-han; et al

doi:10.13406/j.cnki.cyxb.2010.02.023

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Effects of metformin and rosiglitazone in the treatment of polycystic ovarian syndrome with insulin resistance

更新时间：2024-01-17

- Effects of metformin and rosiglitazone in the treatment of polycystic ovarian syndrome with insulin resistance
- Journal of Chongqing Medical University Vol. 35, Issue 2, Pages: 267-270(2010)
- 作者机构：
  
  1. 重庆医科大学附属第一医院辅助生殖中心
  2. 重庆市第三人民医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.02.023
  CLC： R711.75
- Published：2010，
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[1]孙玉菡,吴红.二甲双胍和罗格列酮治疗多囊卵巢综合征的临床疗效观察[J].重庆医科大学学报,2010,35(02):267-270.

SUN Yu-han, et al. Effects of metformin and rosiglitazone in the treatment of polycystic ovarian syndrome with insulin resistance. [J]. Journal of Chongqing Medical University 35(2):267-270(2010)
[1]孙玉菡,吴红.二甲双胍和罗格列酮治疗多囊卵巢综合征的临床疗效观察[J].重庆医科大学学报,2010,35(02):267-270. DOI： 10.13406/j.cnki.cyxb.2010.02.023.

SUN Yu-han, et al. Effects of metformin and rosiglitazone in the treatment of polycystic ovarian syndrome with insulin resistance. [J]. Journal of Chongqing Medical University 35(2):267-270(2010) DOI： 10.13406/j.cnki.cyxb.2010.02.023.

摘要

目的:比较二甲双胍和罗格列酮治疗胰岛素抵抗（Insulin resistance

IR）的多囊卵巢综合征（Polycystic ovarian syndrome

PCOS）患者内分泌、代谢异常的疗效。方法:将45例多囊卵巢综合征伴胰岛素抵抗的患者分为两组

A组给予罗格列酮4 mg/dB组给予二甲双胍850mg/d

治疗4个月

比较治疗前后体重指数（Body mass index

BMI）、腰臀比（Waist-to-hipratio

WHR）、内分泌参数、Homa IR和血脂的变化。结果:两者治疗后

均能使血清睾酮（Testosterone

T）、黄体生成素（Luteinizing hormone

LH）、LH/FSH、空腹胰岛素（Fasting insulin

FINS）、2h胰岛素（2 hINS）、2h血糖（2 hPG）、低密度脂蛋白胆固醇（Low-densitylipoprotein

LDL）的浓度明显下降

Homa IR明显改善（P<0.05）。二甲双胍能降低BMI指数

而罗格列酮能更有效降低T、FINS、2 hINS、Homa IR。结论:罗格列酮比二甲双胍更能改善PCOS患者的胰岛素抵抗

适用于胰岛素抵抗较重的PCOS患者;二甲双胍有降低体重作用

适用于肥胖型PCOS伴胰岛素抵抗不严重者。

Abstract

Objective:To compare the treatment effects of rosiglit azone and me-tformin on endocrine and metabolism in polycystic ovarian syndrome’s(PCOS)patients with insulin resistance.Methods:45 PCOS’s patients were randomly divided into two groups and each group was given rosiglitazone or metformin for 4 months.Changes of body mass index(BMI)

endocrinal hormone and blood lipids were analyzed before and after treatment.Results:There was remarkably decrease in the level of testosterone(T)

luteinizing hormone(LH)

LH/FSH

fasting insulin(FINS)

2 h insulin(2hINS)

2 h plasma glucose(2 hPG)and Homa IR between two groups after treat ment.But BMI was decreased after using metformin

and the level of T

FINS

2 hINS

homa IR were more efficiently decreased after using rosiglitazone.Conclusion:Rosiglitazone

which had better effects on improving insulin resistance and glucose metabolism

affects more conspicuously insulin resistance and hyper insulinemia;While mefformin

which can reduces weight

is suitable for fat PCOS patients with not serious insulin resistance.

关键词

罗格列酮二甲双胍多囊卵巢综合征胰岛素抵抗

Keywords

rosiglitazonemetforminpolycystic ovary syndromeinsulin resistance

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