Experimental study on CGRP and ET-1 before and after endoscopic variceal ligation in liver cirrhosis

XUE Lin-yun; et al

doi:10.13406/j.cnki.cyxb.2010.02.016

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Experimental study on CGRP and ET-1 before and after endoscopic variceal ligation in liver cirrhosis

更新时间：2024-01-17

- Experimental study on CGRP and ET-1 before and after endoscopic variceal ligation in liver cirrhosis
- Journal of Chongqing Medical University Vol. 35, Issue 2, Pages: 234-237(2010)
- 作者机构：
  
  重庆医科大学附属第二医院消化内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.02.016
  CLC： R575.2
- Published：2010，
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[1]薛林云,何松,梅浙川.肝硬化食管静脉曲张套扎术前后降钙素基因相关肽及内皮素水平的观察[J].重庆医科大学学报,2010,35(02):234-237.

XUE Lin-yun, et al. Experimental study on CGRP and ET-1 before and after endoscopic variceal ligation in liver cirrhosis. [J]. Journal of Chongqing Medical University 35(2):234-237(2010)
[1]薛林云,何松,梅浙川.肝硬化食管静脉曲张套扎术前后降钙素基因相关肽及内皮素水平的观察[J].重庆医科大学学报,2010,35(02):234-237. DOI： 10.13406/j.cnki.cyxb.2010.02.016.

XUE Lin-yun, et al. Experimental study on CGRP and ET-1 before and after endoscopic variceal ligation in liver cirrhosis. [J]. Journal of Chongqing Medical University 35(2):234-237(2010) DOI： 10.13406/j.cnki.cyxb.2010.02.016.

摘要

目的:研究肝硬化合并食管静脉曲张患者套扎前后血浆降钙素基因相关肽（Calcitonin gene related peptide

CGRP）及内皮素（Endothelin-1

ET-1）水平的变化

寻找判断食管静脉曲张套扎术后疗效的简易指标。方法:采用酶联免疫分析法测定40例肝硬化（Liver cirrhosis

LC）合并食管静脉曲张（Esophageal varices

EV）患者行食管静脉曲张套扎术（Endoscopic varicealligation

EVL）前后空腹血浆CGRP及ET-1水平。结果:食管静脉曲张套扎前后CGRP及ET-1水平均明显高于正常值

具有显著性意义（P<0.01）。套扎术后CGRP水平显著高于套扎前

具有显著性意义（P<0.05）。部分病例行两次套扎

再次套扎前CGRP水平较上次套扎前后均明显降低

差异有显著性意义（P<0.05）。套扎后ET-1水平较套扎前有所降低

但差异无显著意义。结论:CGRP及ET-1升高在肝硬化门脉高压中起重要作用。套扎后CGRP水平变化情况与临床上套扎后发生上消化道出血的危险性变化相一致

因此CGRP水平可能与出血危险性有相关性。食管静脉曲张套扎术可降低侧枝循环压力

减轻食管静脉曲张程度

改善高动力循环状态。

Abstract

Objective:To investigate the alteration of the level of plasma calcitonin gene related peptide(CGRP)and endothelin-1(ET-1) in liver cirrhosis with esophageal varices(EV)after endoscopic variceal ligation(EVL)

searching for some facility indexes for the judgement of the effect of EVL.Methods:CGRP and ET-1 were measured in plasma sample collected from 40 liver cirrhosis patients with EV before and after EVL by ELISA.Results:Plasma CGRP and ET-1 level were significantly higher than normal

no matter before or after EVL.Plasma CGRP level after EVL was significantly higher than that before EVL(P<0.05).The plasma CGRP level before second EVL of some patients accepted twice EVL was significantly lower than that before or after first EVL.Plasma ET-1 level after EVL was not significantly lower than that before EVL.Conclusion:The increasing of CGRP and ET-1 played an important role in portal hypertension caused by liver cirrhosis.The variation of the level of CGRP corresponded to the risk of upper gastrointestinal bleeding after EVL

so the level of CGRP could be related to the risk of upper gastrointestinal bleeding.The results showed that EVL could cut down the pressure of collateral circulation

and lessen the degree of EV.

关键词

降钙素基因相关肽内皮素肝硬化门静脉高压食管静脉曲张套扎酶联法

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