Changes of local inferior caval vein wall after acute thrombosis with therapeutic alliance in rats

YANG Bing; et al

doi:10.13406/j.cnki.cyxb.2010.02.013

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Changes of local inferior caval vein wall after acute thrombosis with therapeutic alliance in rats

更新时间：2024-01-17

- Changes of local inferior caval vein wall after acute thrombosis with therapeutic alliance in rats
- Journal of Chongqing Medical University Vol. 35, Issue 2, Pages: 262-264(2010)
- 作者机构：
  
  1. 重庆医科大学附属第一医院护理学院
  2. 重庆医科大学附属第一医院护理部
  3. 重庆医科大学附属第一医院血管外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.02.013
  CLC： R543.6
- Published：2010，
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[1]杨冰,赵庆华,赵渝.溶栓抗凝联合治疗大鼠急性血栓后对局部管壁的影响[J].重庆医科大学学报,2010,35(02):262-264.

YANG Bing, et al. Changes of local inferior caval vein wall after acute thrombosis with therapeutic alliance in rats. [J]. Journal of Chongqing Medical University 35(2):262-264(2010)
[1]杨冰,赵庆华,赵渝.溶栓抗凝联合治疗大鼠急性血栓后对局部管壁的影响[J].重庆医科大学学报,2010,35(02):262-264. DOI： 10.13406/j.cnki.cyxb.2010.02.013.

YANG Bing, et al. Changes of local inferior caval vein wall after acute thrombosis with therapeutic alliance in rats. [J]. Journal of Chongqing Medical University 35(2):262-264(2010) DOI： 10.13406/j.cnki.cyxb.2010.02.013.

摘要

目的:研究尿激酶、肝素及其联合治疗急性大鼠下腔静脉血栓（Deep venous thrombosis

DVT）形成后不同时相静脉血栓与血管粘附特性的变化。方法:SD大鼠140只

105只建立大鼠急性下腔静脉血栓模型后随机分为肝素治疗A组、尿激酶治疗B组、联合治疗C组各35只;另35只为假手术组（sham

SH）。各组给药后分别于血栓形成后第1、4、7、14、28 d获取目标血管

光镜观察血栓的结构演变与机化、内膜增生程度

检测静脉壁平滑肌胶原沉积量

以及力学测量管壁血栓附着力。结果:A组内膜增生最严重。栓后1、4 d

B、C组血栓附着力分别较A组低（P<0.01）。结论:尿激酶加肝素治疗大鼠急性下腔静脉血栓形成能有效地保护内皮层完整

减轻血管内膜增生

但在溶栓抗凝联合治疗急性血栓后残余附壁血栓粘附力相对较低

不建议早期运动加压。

Abstract

Objective:To study the changes of thrombotic adhersion property and inferior caval vein wall after acute thrombosis with therapeutic alliance in rats.Methods:The inferior caval venous thrombosis model were treated with heparin(group A

n=35)

urokinase (group B

n=35)

and the combination of heparin and urokinase(group C

n =35)

respectively.(group SH

n =35).The thrombosed caval veins were taken 1

and 28 days after thrombosis.The changes of thrombotic tructure and intima hyperplasia.were observed by light microscope The power of adhesion of thrombosis was measured on different phases.Results:The endothelium damage in group A was serious than that in group B and C on day 7(P<0.05)

and the endothelium damage in group C was less than that in the group B and C on day 28(P<0.05).Adhesion to caval vein wall in group B and C was lower than group A since day 4 after thrombosis(all P<0.01). Conclusion:Combination of heparin and urokinase for the treatment of acute inferior caval venous thrombosis effectively maintains the integrity of endotheliunm of vein wall and decreases the fibro-cellular proliferation of the thrombosed vein.Adhesion to caval vein wall in group C is relatively lower in the earlier period after thrombosis.

关键词

静脉血栓形成抗凝溶栓内膜增生粘附

Keywords

venous thrombosisAnticoagulation thrombolysisintimal hyperplasiaAdhesion

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