Effect of pioglitazone on expression of ICAM-1 in an atherosclerotic rabbit aorta

XU Qing-hua; et al

doi:10.13406/j.cnki.cyxb.2010.02.010

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Effect of pioglitazone on expression of ICAM-1 in an atherosclerotic rabbit aorta

更新时间：2024-01-17

- Effect of pioglitazone on expression of ICAM-1 in an atherosclerotic rabbit aorta
- Journal of Chongqing Medical University Vol. 35, Issue 2, Pages: 216-219(2010)
- 作者机构：
  
  1. 福建医科大学附属泉州第一医院呼吸科
  2. 福建省立医院福建省心血管病研究所心内科
  3. 福建省心血管病重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.02.010
  CLC： R543.5
- Published：2010，
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[1]许庆华,关瑞锦,韩莉莉,李小林,王洪燕.吡格列酮对兔动脉粥样硬化血管壁ICAM-1表达的影响[J].重庆医科大学学报,2010,35(02):216-219.

XU Qing-hua, et al. Effect of pioglitazone on expression of ICAM-1 in an atherosclerotic rabbit aorta. [J]. Journal of Chongqing Medical University 35(2):216-219(2010)
[1]许庆华,关瑞锦,韩莉莉,李小林,王洪燕.吡格列酮对兔动脉粥样硬化血管壁ICAM-1表达的影响[J].重庆医科大学学报,2010,35(02):216-219. DOI： 10.13406/j.cnki.cyxb.2010.02.010.

XU Qing-hua, et al. Effect of pioglitazone on expression of ICAM-1 in an atherosclerotic rabbit aorta. [J]. Journal of Chongqing Medical University 35(2):216-219(2010) DOI： 10.13406/j.cnki.cyxb.2010.02.010.

摘要

目的:探讨吡格列酮对动脉粥样硬化（Atherosclerosis

AS）血管壁细胞间粘附分子（Intercellular adhesion molecule-1

ICAM-1）表达的影响。方法:新西兰兔随机分成5组:A:正常对照

B:正常+低剂量吡格列酮（Pioglitazone

PIO）

C:病理对照

D:病理+低剂量PIO

E:病理+高剂量PIO。采用免疫组化及逆转录聚合酶链反应（RT-PCR）的方法观察吡格列酮血管壁ICAM-1蛋白及mRNA表达的影响。结果:AS斑块内有ICAM-1蛋白和mRNA高表达

PIO可抑制ICAM-1蛋白和mRNA表达（P<0.05）

高剂量较低剂量抑制程度更大（P<0.05）。结论:PIO可抑制AS斑块ICAM-1的mRNA和蛋白表达

进而发挥抗AS炎症的作用。

Abstract

Objective:To explore the effect of pioglitazone(PIO)on expression of intercellular adhesion molecule-1(ICAM-1)in atherosclerotic rabbit aorta.Methods:Newzealand white rabbits were divide into 5 groups:normal control

normal+low dose of PIO

and AS control

AS+low dose of PIO

AS+high dose of PIO.Immunohistochemistry was used to detect the protein of ICAM-1.Reverse transcription-polymerase chain reaction(RT-PCR)was used to detect the mRNA of ICAM-1.Results:ICAM-1 protein and mRNA in AS plaques.PIO could inhibit the expression of ICAM-1 protein and mRNA(P<0.05).The effect of high dose was more than that of were highly expressed low dose(P<0.05).Conclusion:PIO could inhibit the expression of ICAM-1 and further produce its anti-inflammatory effect on AS.

关键词

动脉粥样硬化吡格列酮噻唑烷二酮细胞间黏附分子-1炎症

Keywords

atherosclerosispioglitazoneThiazolidinedionsICAM-1inflammation

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