Effect of EGb on cardiac hypertrophy induced by isoproterenol in rat

GOU Huai-yu; et al

doi:10.13406/j.cnki.cyxb.2010.02.004

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Effect of EGb on cardiac hypertrophy induced by isoproterenol in rat

更新时间：2024-01-17

- Effect of EGb on cardiac hypertrophy induced by isoproterenol in rat
- Journal of Chongqing Medical University Vol. 35, Issue 2, Pages: 224-226(2010)
- 作者机构：
  
  1. 重庆市渝北区人民医院心内科
  2. 重庆医科大学附属第二医院心内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.02.004
  CLC： R285.5
- Published：2010，
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[1]苟怀宇,陈艳秋,黄晶,邓昌明,刘地川,江永红.银杏叶提取物对异丙肾上腺素诱导的大鼠心肌肥厚的影响[J].重庆医科大学学报,2010,35(02):224-226.

GOU Huai-yu, et al. Effect of EGb on cardiac hypertrophy induced by isoproterenol in rat. [J]. Journal of Chongqing Medical University 35(2):224-226(2010)
[1]苟怀宇,陈艳秋,黄晶,邓昌明,刘地川,江永红.银杏叶提取物对异丙肾上腺素诱导的大鼠心肌肥厚的影响[J].重庆医科大学学报,2010,35(02):224-226. DOI： 10.13406/j.cnki.cyxb.2010.02.004.

GOU Huai-yu, et al. Effect of EGb on cardiac hypertrophy induced by isoproterenol in rat. [J]. Journal of Chongqing Medical University 35(2):224-226(2010) DOI： 10.13406/j.cnki.cyxb.2010.02.004.

摘要

目的:研究银杏叶提取物（Extract of ginkgo biloba

EGb）对异丙肾上腺素（Isoprenaline

Iso）诱导的大鼠心肌肥厚的影响。方法:大鼠30只分为正常对照组、ISO模型组和EGb治疗组。测定全心重量指数（Heart weight/Body weight

HW/BW）、左心室重量指数（Left ventricle weight index

LVI）;检测左心室心肌组织中丙二醛（Malondialdehyde

MDA）和超氧化物歧化酶（Superoxidedismutase

SOD）、谷光苷肽过氧化酶（Glutathione-SH pexoxidase

GSH-Px）、一氧化氮合成酶（Nitric oxide synthetase

NOS）活性。结果:ISO模型组的HW/BW、LVI、左心室MDA含量和诱生型NOS（Inducible nitric oxide synthase

iNOS）活性显著高于正常对照组（P<0.05）

SOD、GSH-Px及结构型NOS（Constitutive nitric oxide synthase

cNOS）活性比正常对照组低（P<0.05）;EGb治疗组左心室MDA含量、iNOS活性和心脏重量指数比ISO模型组低（P<0.05）

SOD、GSH-Px和cNOS活性明显高于ISO模型组（P<0.05）。结论:EGb对ISO诱导的心肌肥厚的发生有预防作用。

Abstract

Objective:To study the effect of EGb on cardiac hypertrophy induced by isoproterenol in rats.Methods:30 rats were randomly divided into 3 groups:normal control group

ISO model group and EGb treatment group.The ratio of HW/BW and LVI were measured.MDA content of left ventricle and the level of SOD

GSH-Px and NOS activities in left ventricle were determined.Results:Compared with normal control group

the ratio of HW/BW

LVI and the content of MDA and iNOS activity in left ventricle were significantly increased(P<0.05); The SOD

GSH-Px and cNOS activities were obviously decreased in the ISO model group(P<0.05).The left ventricular MDA and iNOS activity and the ratio of HW/BW

LVI were significantly lower in EGb treatment group than those in ISO model group(P<0.05).The SOD

GSH-Px and cNOS activities were markedly higher than those in ISO model group.Conclusion:EGb can prevent the cardiac hypertrophy induced by isoproterenol.

关键词

银杏叶提取物异丙肾上腺素心肌肥厚

Keywords

Extract of ginkgo bilobaisoproterenolcardiac hypertrophy

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