Expression of CD133 in bladder cancer and their clinical significance

LI Rui; et al

doi:10.13406/j.cnki.cyxb.2010.01.045

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Expression of CD133 in bladder cancer and their clinical significance

更新时间：2024-01-17

- Expression of CD133 in bladder cancer and their clinical significance
- Journal of Chongqing Medical University Vol. 35, Issue 1, Pages: 76-79(2010)
- 作者机构：
  
  重庆医科大学附属第一医院泌尿外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.01.045
  CLC： R737.14
- Published：2010，
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[1]李瑞,唐伟.CD133在膀胱移行细胞癌的表达及临床意义[J].重庆医科大学学报,2010,35(01):76-79.

LI Rui, et al. Expression of CD133 in bladder cancer and their clinical significance. [J]. Journal of Chongqing Medical University 35(1):76-79(2010)
[1]李瑞,唐伟.CD133在膀胱移行细胞癌的表达及临床意义[J].重庆医科大学学报,2010,35(01):76-79. DOI： 10.13406/j.cnki.cyxb.2010.01.045.

LI Rui, et al. Expression of CD133 in bladder cancer and their clinical significance. [J]. Journal of Chongqing Medical University 35(1):76-79(2010) DOI： 10.13406/j.cnki.cyxb.2010.01.045.

摘要

目的:研究CD133在膀胱移行细胞癌（Transitional cell carcinoma of bladder

TCCB）中的表达

并探讨其在膀胱移行细胞癌发生发展中的作用。方法:采用半定量RT-PCR及免疫组织化学S-P法方法检测50例膀胱癌组织及43例癌旁正常组织中CD133的表达。结果:50例膀胱移行细胞癌中

CD133蛋白阳性表达率为78%（39/50）

CD133mRNA阳性表达率为84%（42/50）;43例癌旁组织中CD133蛋白阳性表达率为16.28%（7/43）

CD133mRNA表达阳性率为13.95%（6/43）

CD133蛋白和mRNA在癌组织和癌旁正常膀胱组织表达有显著差异（P<0.01）。临床病理资料的相关性分析显示

膀胱移行细胞癌中

CD133mRNA和蛋白的表达分布与性别无关（P>0.05

）与病理分级、分化程度等相关（P<0.05）。结论:CD133在膀胱癌中的表达明显高于在癌旁组织中的表达;CD133在膀胱移行细胞癌中的表达与性别无相关性

与病理分级、临床分期有无淋巴结转移等相关;CD133有望成为判断膀胱移行细胞癌的病情发展及指导临床治疗的有用指标。

Abstract

Objective:To investigate the expressions of CD133 in bladder cancerand elucidate the roleof CD133 protein and mRNAin the development of human bladder transitional cell carcinoma(TCCB).Methods:The expression of CD133 in 50 cases of human TCCB tissue and 43 cases of adjacent normal bladder tissue were detected by Immunohistochemistry S-P and Reverse transcription polymerase chain reaction(RT-PCR)

respectively.The correlation was analysed statistically

between the expression of CD133 protein and mRNA and clinicopathological parameters of human TCCB.Results:The positive rate of CD133 protein and mRNA in malignant specimens was 78.0%(39/50)and 84%(42/50)

respectively

while that in the adjacent normal bladder tissue was 16.28%(7/43)and 13.95%(6/43)

respectively.The expression of CD133 protein and mRNA was significantly different between TCCB tissue and adjacent normal bladder tissue(P<0.01).The further statistical analysis showed that the CD133 protein and mRNA expression was correlated to the pathology grades of BTCC(P<0.05)

but had no correlation to the sex of TCCB(P>0.05).Conclusion:Different expression of CD133 gene is correlated to invasion and metastasis of TCCB.CD133 may be one of the markers for assessment of the progress of the cancer and clinical prognosis for TCBB.

关键词

CD133膀胱肿瘤肿瘤干细胞免疫组织化学逆转录聚合酶链反应

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