Protein expression of Maspin,P53 and Skp2 in colorectal tumors and their significance

NI Jiang-tao; et al

doi:10.13406/j.cnki.cyxb.2010.01.039

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Protein expression of Maspin,P53 and Skp2 in colorectal tumors and their significance

更新时间：2024-01-17

- Protein expression of Maspin,P53 and Skp2 in colorectal tumors and their significance
- Journal of Chongqing Medical University Vol. 35, Issue 1, Pages: 29-33(2010)
- 作者机构：
  
  重庆医科大学病理教研室分子医学及肿瘤研究中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.01.039
  CLC： R735.34
- Published：2010，
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[1]倪江涛,易永芬,石海鹏.Maspin、P53、Skp2蛋白在结直肠肿瘤中的表达及其意义[J].重庆医科大学学报,2010,35(01):29-33.

NI Jiang-tao, et al. Protein expression of Maspin,P53 and Skp2 in colorectal tumors and their significance. [J]. Journal of Chongqing Medical University 35(1):29-33(2010)
[1]倪江涛,易永芬,石海鹏.Maspin、P53、Skp2蛋白在结直肠肿瘤中的表达及其意义[J].重庆医科大学学报,2010,35(01):29-33. DOI： 10.13406/j.cnki.cyxb.2010.01.039.

NI Jiang-tao, et al. Protein expression of Maspin,P53 and Skp2 in colorectal tumors and their significance. [J]. Journal of Chongqing Medical University 35(1):29-33(2010) DOI： 10.13406/j.cnki.cyxb.2010.01.039.

摘要

目的:研究maspin、p53及skp2蛋白在结直肠肿瘤组织中的表达及临床病理意义。方法:采用免疫组织化学法检测maspin、p53及skp2在50例结直肠腺癌

20例结直肠腺瘤、20例正常结直肠粘膜组织中的表达。结果:maspin蛋白在结直肠腺瘤和正常结直肠粘膜组织中的表达均高于结直肠腺癌（P<0.05）;无淋巴结转移组maspin表达率高于淋巴结转移组（P<0.05）;DukesC

D期结直肠癌组织maspin表达率低于DukesA、B期（P<0.05）。在结直肠腺癌及腺瘤中maspin与p53的表达均呈负相关（P<0.01）

然而在skp2与maspin、skp2与p53之间没有发现相关性（P>0.05）。结论:maspin的表达可能受p53基因的调控。联合检测maspin、p53及skp2在结直肠肿瘤中表达水平

对判定结直肠癌恶性程度及预后可能具有重要参考价值。

Abstract

Objective:Toinvestigate the role ofmaspin

p53 and Skp2 expression in the progression ofcolorectal tumors

and tounderstand their clinicopathological significance.Methods:The expression of maspin

p53 and Skp2 in colorectal adenocarcinoma(n=50)

adenoma(n=20)and normal tissue(n=20)were detected by immunohistochemistry and compared with the clinicopathological tumor parameters.The relationship among the expression of maspin

p53

and Skp2 was also analyzed in colorectal tumors.Results:Maspin expression was much lower in colorectal adenocarcinoma than in adenoma and normal tissues(P<0.05).Maspin expression showed a negative association with lymphatic metastasis and higher Dukes stage(P<0.05).Expression of maspin protein was negatively correlated with p53 expression(P<0.01).However

there was no significant correlation between expression of Skp2 and p53 or maspin(P>0.05).Conclusion:Maspin might be regulated by the p53 pathway.Combined detection of the expression of maspin

p53

and skp2 may be useful for evaluating its infiltration

metastasis and prognosis.

关键词

maspinp53skp2结直肠肿瘤

Keywords

maspinp53Skp2Colorectal tumor

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