Expression profile analysis of human spontaneous abortion extravillous trophoblast cells

YU Qiu-bo; et al

doi:10.13406/j.cnki.cyxb.2010.01.024

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Expression profile analysis of human spontaneous abortion extravillous trophoblast cells

更新时间：2024-01-17

- Expression profile analysis of human spontaneous abortion extravillous trophoblast cells
- Journal of Chongqing Medical University Vol. 35, Issue 1, Pages: 18-22(2010)
- 作者机构：
  
  1. 重庆医科大学公共卫生学院生殖毒理教研室
  2. 重庆医科大学公共卫生学院遗传优生教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.01.024
  CLC： R714.21
- Published：2010，
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[1]余秋波,胡建刚,王应雄,黎刚,谭彬,何俊琳.自然流产患者绒毛EVTs的基因芯片初步分析[J].重庆医科大学学报,2010,35(01):18-22.

YU Qiu-bo, et al. Expression profile analysis of human spontaneous abortion extravillous trophoblast cells. [J]. Journal of Chongqing Medical University 35(1):18-22(2010)
[1]余秋波,胡建刚,王应雄,黎刚,谭彬,何俊琳.自然流产患者绒毛EVTs的基因芯片初步分析[J].重庆医科大学学报,2010,35(01):18-22. DOI： 10.13406/j.cnki.cyxb.2010.01.024.

YU Qiu-bo, et al. Expression profile analysis of human spontaneous abortion extravillous trophoblast cells. [J]. Journal of Chongqing Medical University 35(1):18-22(2010) DOI： 10.13406/j.cnki.cyxb.2010.01.024.

摘要

目的:探讨自然流产绒毛外滋养细胞（Extravillous trophoblast cells

EVTs）侵袭相关基因表达变化。方法:利用U133plus2.0芯片对自然流产绒毛和正常绒毛组织中EVTs的基因表达谱进行检测

并用生物信息学方法对检测结果进行分析。结果:与正常EVTs相比

在自然流产EVTs中

发现显著上调基因219个

下调基因293个

其功能主要涉及细胞粘附、免疫应答、代谢等。结论:与滋养层细胞细胞粘附、免疫应答、水解酶及凋亡等相关基因的差异表达可能与滋养细胞侵袭行为变化及自然流产有关。

Abstract

Objective:To investigate the expression changes ofinvasion-relevant genes in spontaneous abortion Extravillous trophoblast cells(EVTs).Methods:The U133 plus2.0 gene chips were used to analyze gene expression profiles in spontaneous EVTs and normal EVTs.The results were analyzed by bioinformatics methods.Results:Compared with normal EVTs

219 and 293 genes in spontaneous abortion EVTs were up-regulated and down-regulated respectively.These genes were mainly associated with signal transduction

apoptosis

metabolism

immune response

etc.Conclusion:Differential expression of genes related with apoptosis

immune response

hydratase

cell adhesion may play a role in the EVTs’abnormal invasion and spontaneous abortion.

关键词

自然流产EVTs侵袭基因表达谱

Keywords

spontaneous abortionEVTsinvasionGeneexpression profiles

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Related Author

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Related Institution

Department of Gastrointestinal Surgery，The Third Affiliated Hospital of Zunyi Medical University/ The First People’s Hospital of Zunyi

Central Laboratory of Yongchuan Hospital Affiliated to Chongqing Medical University

Department of Obstetrics and Gynecology,The First Affiliated Hospital of Chongqing Medical University

Department of Obstetrics and Gynecology,Yongchuan Hospital Affiliated to Chongqing Medical University

Department of Stomatology，Tangshan Vocational and Technical College

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