Relationship between glycated albumin levels and diabetic nephropathy in patients with type 2 diabetes mellitus

ZHANG Jin

doi:10.13406/j.cnki.cyxb.2010.01.018

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Relationship between glycated albumin levels and diabetic nephropathy in patients with type 2 diabetes mellitus

更新时间：2024-01-17

- Relationship between glycated albumin levels and diabetic nephropathy in patients with type 2 diabetes mellitus
- Journal of Chongqing Medical University Vol. 35, Issue 1, Pages: 113-115(2010)
- 作者机构：
  
  四川省乐山市人民医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.01.018
  CLC： R587.1
- Published：2010，
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[1]张晋.2型糖尿病患者血清糖化白蛋白水平与糖尿病肾病的相关性分析[J].重庆医科大学学报,2010,35(01):113-115.

ZHANG Jin. Relationship between glycated albumin levels and diabetic nephropathy in patients with type 2 diabetes mellitus. [J]. Journal of Chongqing Medical University 35(1):113-115(2010)
[1]张晋.2型糖尿病患者血清糖化白蛋白水平与糖尿病肾病的相关性分析[J].重庆医科大学学报,2010,35(01):113-115. DOI： 10.13406/j.cnki.cyxb.2010.01.018.

ZHANG Jin. Relationship between glycated albumin levels and diabetic nephropathy in patients with type 2 diabetes mellitus. [J]. Journal of Chongqing Medical University 35(1):113-115(2010) DOI： 10.13406/j.cnki.cyxb.2010.01.018.

摘要

目的:探讨2型糖尿病患者血清糖化白蛋白与糖尿病肾病的相关性。方法:2006年1月至2009年6月入我院治疗的2型糖尿病患者78例采用液态酶法检测血清糖化白蛋白

并与同期50例健康对照组比较。结果:健康对照组和2型糖尿病患者的糖尿病肾病组之间血清糖化白蛋白均有差异（F=8.953

P=0.0001）。糖尿病各组血清糖化白蛋白高于健康对照组;糖尿病肾病各组高于非糖尿病肾病组;终末期糖尿病肾病组糖化白蛋白高于其余各组。并且糖尿病肾病的严重程度和糖化白蛋白水平相关

rs为0.754（t=6.547

P=0.008）。有序Logistic回归分析显示

糖化白蛋白是影响糖尿病肾病发病及病情严重程度的独立危险因素

多因素调整后的OR值为2.326

95%CI为2.114～2.538。结论:糖化白蛋白在糖尿病肾病发病中起重要作用

并且和糖尿病肾病的分期密切相关。

Abstract

Objective:To investigate the relationship between glycated albumin levels and diabetic nephropathyin patients with type 2 diabetes mellitus.Methods:From January 2006 to June 2009

78 patients with type 2 diabetes mellitus in our hospital were enrolled in the study.We used liquid enzymatic to detect glycated albumin

and compare with 50 cases of healthy in the same period as the control group.Results:The glycated albumin was different between the control group and the diabetic nephropathy groups(F= 8.953

P=0.000).Glycated albumin in each diabetes group was higher than that in the control group;glycated albumin in diabetic nephropathy groups was higher than that in non-diabetic nephropathy group;glycated albumin in end-stage diabetic nephropathy group was higher than that in the rest of groups.The severity of diabetic nephropathy and level of glycated albumin were related

rs was 0.754(t=6.547

P=0.008).Logistic regression showed that glycated albumin was an independent risk factor impacting on the incidence of diabetic nephropathy and the severity of the disease

multi-adjusted OR value was 2.326

and 95% CI was 2.114-2.538.Conclusions:Glycated albumin plays an important role in the pathogenesis of diabetic nephropathy

and it is closely related to the phases of diabetic nephropathy.

关键词

2型糖尿病血清糖化白蛋白糖尿病肾病危险因素发病机制

Keywords

type 2 diabetes mellitusGlycosylated albumindiabetic nephropathyrisk factorspathogenesis

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Related Institution

Department of Endocrinology，Shanghai Pudong Hospital/Fudan University Pudong Medical Center

Department of Nephrology，The Second Affiliated Hospital of Chongqing Medical University

The First College of Clinical Medicine，Yunnan University of Chinese Medicine

Department of Endocrinology，The First People’s Hospital of Yunnan Province/Affiliated Hospital of Kunming University of Science and Technology

NHC Key Laboratory of Hormones and Development，Tianjin Key Laboratory of Metabolic Diseases，Tianjin Institute of Endocrinology，Department of Clinical Laboratory，Chu Hsien-I Memorial Hospital，Tianjin Medical University

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