An experimental study on the protective effects of shenfu injection for myocardial ischemia-reperfusion injury in rats

SU Hong-jie; et al

doi:10.13406/j.cnki.cyxb.2010.01.001

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An experimental study on the protective effects of shenfu injection for myocardial ischemia-reperfusion injury in rats

更新时间：2024-01-17

- An experimental study on the protective effects of shenfu injection for myocardial ischemia-reperfusion injury in rats
- Journal of Chongqing Medical University Vol. 35, Issue 1, Pages: 60-64(2010)
- 作者机构：
  
  1. 重庆医科大学附属第一医院胸心外科
  2. 重庆市急救医疗中心胸心外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.01.001
  CLC： R285.5
- Published：2010，
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[1]苏泓洁,向小勇,赵兴吉,都定元.参附注射液对大鼠心肌缺血再灌注损伤保护作用的实验研究[J].重庆医科大学学报,2010,35(01):60-64.

SU Hong-jie, et al. An experimental study on the protective effects of shenfu injection for myocardial ischemia-reperfusion injury in rats. [J]. Journal of Chongqing Medical University 35(1):60-64(2010)
[1]苏泓洁,向小勇,赵兴吉,都定元.参附注射液对大鼠心肌缺血再灌注损伤保护作用的实验研究[J].重庆医科大学学报,2010,35(01):60-64. DOI： 10.13406/j.cnki.cyxb.2010.01.001.

SU Hong-jie, et al. An experimental study on the protective effects of shenfu injection for myocardial ischemia-reperfusion injury in rats. [J]. Journal of Chongqing Medical University 35(1):60-64(2010) DOI： 10.13406/j.cnki.cyxb.2010.01.001.

摘要

目的:探讨参附注射液（Shenfuinjection

SFI）对心肌缺血再灌注损伤（Myocardial ischemia-reperfusion injury

MIRI）的功效。方法:通过复制大鼠心肌缺血再灌注损伤模型

观察SFI不同剂量对心肌缺血再灌注损伤的保护作用。结果:SFI高剂量组对大鼠心肌缺血再灌注损伤模型组在给药后30、60、120min能明显降低大鼠ECG的ST段和T波的偏移

有显著性差异（P<0.05）;在给药后120min能明显降低大鼠血清CK、CK-MB、LDH和MMP-9的活性

有显著性差异（P<0.05）;还能显著降低大鼠心室脏器系数

使其心肌梗塞面积明显缩小

梗塞区重量减轻

明显改善心肌缺血状况;对冠脉结扎再灌注损伤大鼠全血粘度（低切）和血浆粘度的升高有一定的降低作用。结论:SFI对大鼠心肌缺血再灌注损伤有明显的保护作用

为其临床应用提供了进一步的实验室依据。

Abstract

Objective:To investigate the function ofshenfu injection in myocardial ischemia-reperfusion injury(MIRI).Methods:To observe the effects of Shenfu injection(SFI)in different dosages.An experimental rat’s model of myocardial ischemia-reperfusion inury(MIRI)was created.Results:The high-dosed-Shenfu-injection(SFI)group(20 ml/kg)compared with the MIRI model group showed significant depressant effect on the ECG ST segment and T wave after 30

120 minutes

respectively

of the injection.Such differences were of great statistical value(P<0.05).Similarly

a reduced serum CK

CK-MB

LDH

MMP-9 activity occurred 120 minutes after the injection(P<0.05).It could significantly reduce the area and extent of myocardial infarction

obviously improve the situation of myocardial ischemia.It showed a certain reducing effect in the increased whole blood viscosity(low shear)and plasma viscosity.Conclusion:SFI contributing a valid protective effect in myocardial ischemia-reperfusion injury was indeed significant and served as a contributing laboratory basis for further clinical application.

关键词

参附注射液心肌缺血再灌注损伤基质金属蛋白酶-9

Keywords

Shenfu injectionmyocardial ischemia-reperfusion injurymatrix metalloproteinase-9

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