Effect of therapeutic alliance of radiofrequency ablation and high-frequency thermotherapy on the invasion of cony liver cancer cell line VX2

TANG Rong

doi:10.13406/j.cnki.cyxb.2008.05.021

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Effect of therapeutic alliance of radiofrequency ablation and high-frequency thermotherapy on the invasion of cony liver cancer cell line VX2

更新时间：2024-01-17

- Effect of therapeutic alliance of radiofrequency ablation and high-frequency thermotherapy on the invasion of cony liver cancer cell line VX2
- Journal of Chongqing Medical University Issue 5, Pages: 564-569(2008)
- 作者机构：
  
  1. 重庆医科大学附属第一医院血管外科
  2. 重庆市第八人民医院外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2008.05.021
  CLC： R735.7
- Published：2008，
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[1]唐荣,乔正荣,吴华平,张国武.射频消融联合高频热疗对兔肝VX2肿瘤侵袭能力的影响[J].重庆医科大学学报,2008(05):564-569.

TANG Rong. Effect of therapeutic alliance of radiofrequency ablation and high-frequency thermotherapy on the invasion of cony liver cancer cell line VX2. [J]. Journal of Chongqing Medical University (5):564-569(2008)
[1]唐荣,乔正荣,吴华平,张国武.射频消融联合高频热疗对兔肝VX2肿瘤侵袭能力的影响[J].重庆医科大学学报,2008(05):564-569. DOI： 10.13406/j.cnki.cyxb.2008.05.021.

TANG Rong. Effect of therapeutic alliance of radiofrequency ablation and high-frequency thermotherapy on the invasion of cony liver cancer cell line VX2. [J]. Journal of Chongqing Medical University (5):564-569(2008) DOI： 10.13406/j.cnki.cyxb.2008.05.021.

摘要

目的:研究射频消融（radiofrequency ablation

RFA）联合高频热疗（High freguency hyperthermia

HFH）对兔肝VX2肿瘤侵袭能力的改变。方法:采用RFA和HFH治疗

用移植的方法建立兔肝VX2肿瘤模型

按治疗方法不同随机分为4组:空白组（A组

8只）;RAF组（B组

8只）;HFH组（C组

8只）;RFA+HFH联合治疗组（D组

8只）。结果:（1）肿瘤体积:B组、D组肿瘤体积在治疗后第14d明显缩小

B组、D组组内比较（P<0.05）

D组缩小最明显

D组与B、C组组组间比较有明显差异（P<0.05）。A组及C组肿瘤体积继续增大

A组增大显著高于各治疗组（P<0.05）。（2）治疗14d后MMP-2、MMP-9、CD34阳性表达:肿瘤中心组织中

各指标阳性表达率在B组、D组中最低

在A组最高

C组与A组组间比较有明显差异（P<0.05）;肿瘤边缘组织中

治疗组的各指标阳性表达率均比与A组低

与A组比较均有明显差异（P<0.05）

D组中各指标阳性表达率最低

D组与B组、C组比较均有明显差异（P<0.05）。结论:RFA

HFH 2种热疗方法均可降低肿瘤的侵袭力

将二者联合运用

降低肿瘤侵袭力的作用更明显。

Abstract

Objective:To study the effect of therapeutic alliance of radiofrequency ablation(RFA) and high-frequency thermotherapy(HFH) on the invasion of cony liver cancer cell line VX2.Methods:The cony liver cancer VX2 model was prepared by transplantion

according to the different treatment methods

the models were divided into four groups:Control group (group A 8);RAF group (group B 8)

HFH group (group C 8);The therapeutic alliance of RFA+HFH group (group D 8). Results:(1)Gross tumor volume:the tumor volume of group B and D deflated significantly post-treatment 14 days

the group B and D compared within groups(P<0.05)

the group D deflated more obviously.the group D compared with B and C

the group D deflated significantly(P<0.05).The tumor volume in group A augmented

the augmention in group A was more than every treatment groups(P<0.05).(2)The expression of MMP-2

MMP-9 and CD34:In the tumor central tissue

the expression of every index was the lowest in group B and D

the highest in group A

the group C compared with the group A was different significantly(P<0.05)

the index in group D was the lowest

the group D compared with group B and C was different significantly(P<0.05).Conclusion:The thermotherapy methods RFA and HFH can depress the invasion of the tumor cells

but the effect of the therapeutic alliance of RFA+HFH was more obviously.

关键词

射频消融高频热疗肝肿瘤侵袭转移

Keywords

radiofrequency ablationHigh frequency hyperthermiaTumor of liverinvasion and metastasis

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