The expression and significance of P-gp and GST-n in colorectal carcinoma

XU Qiao-yuan

doi:10.13406/j.cnki.cyxb.2008.03.026

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The expression and significance of P-gp and GST-n in colorectal carcinoma

更新时间：2024-01-17

- The expression and significance of P-gp and GST-n in colorectal carcinoma
- Journal of Chongqing Medical University Issue 3, Pages: 317-319(2008)
- 作者机构：
  
  1. 重庆医科大学附属第一医院肿瘤科
  2. 重庆医科大学附属第一医院肿瘤科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2008.03.026
  CLC： R735.34
- Published：2008，
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[1]徐巧元,张幸平.P-gp、GST-π在大肠癌中的表达及意义[J].重庆医科大学学报,2008(03):317-319+381.

XU Qiao-yuan. The expression and significance of P-gp and GST-n in colorectal carcinoma. [J]. Journal of Chongqing Medical University (3):317-319(2008)
[1]徐巧元,张幸平.P-gp、GST-π在大肠癌中的表达及意义[J].重庆医科大学学报,2008(03):317-319+381. DOI： 10.13406/j.cnki.cyxb.2008.03.026.

XU Qiao-yuan. The expression and significance of P-gp and GST-n in colorectal carcinoma. [J]. Journal of Chongqing Medical University (3):317-319(2008) DOI： 10.13406/j.cnki.cyxb.2008.03.026.

摘要

目的:探讨P-糖蛋白（P-glycoproteins

P-gp）和谷光甘肽-S-转移酶-π（Glutathione-s-transferase-π

GST-π）在大肠癌中的表达及意义。方法:应用免疫组化MaxVision

二步法

检测78例大肠癌、31例癌旁正常肠黏膜中P-gp和GST-π的表达。结果:P-gp、GST-π在78例大肠癌组织中的阳性表达率分别为83.3%和85.9%

均高于正常肠黏膜组织（P

0.05）。P-gp的表达与浸润深度存在正相关（P

0.05）。P-gp、GST-π的表达存在正相关（P

0.05）。结论:P-gp和GST-π在大肠癌中均高表达

在大肠癌原发性多药耐药中起重要作用。联合检测P-gp和GST-π在大肠癌中的表达对判断预后及临床用药有重要意义。

Abstract

Objective:To study the expression and significance of P-gp and GST-πin colorectal carcinoma.Methods: Immunohistochemistry was used to examine the P-gp and GST-πexpression in 78 cases of colorectal carcinoma and 31 cases of normal colorectal tissues.Resu/ts:The positive expression rates of P-gp and GST-πin colorectal carcinoma were 83.3% and 85.9% respectively

higher than those in normal colorectal tissues.The expression of P-gp was related to the degree of invasion(P<0.05).Some correlation was found between P-gp and GST-π.Conclusions:P-gp and GST-πplay important roles in the primary muttidrug resistance of colorectal carcinoma.Detecting the expression of P-gp and GST-πin colorectal carcinoma has the referential significance with regard to the choice of drugs and plan in colorectal carcinoma chemotherapy.

关键词

大肠癌P-糖蛋白谷光甘肽-S-转移酶-π

Keywords

Colorectal carcinomaP-glycoproteinsGlutathione-s-transferase-π

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Department of Surgery, Second College of Clinical Medicine，Chongqing Medical University

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