The effect of yemazhui on concentration of levofloxacin in rinse solution of mice tracheae

ZHA NG Sihan et; al

doi:10.13406/j.cnki.cyxb.2007.12.035

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The effect of yemazhui on concentration of levofloxacin in rinse solution of mice tracheae

更新时间：2024-01-17

- The effect of yemazhui on concentration of levofloxacin in rinse solution of mice tracheae
- Journal of Chongqing Medical University Issue 12, Pages: 1311-1313(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院临床药理研究室
  2. 重庆医科大学附属第一医院临床药理研究室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2007.12.035
  CLC： R969.2
- Published：2007，
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[1]张斯汉,周远大,何海霞.野马追对小鼠气管冲洗液中左氧氟沙星浓度的影响[J].重庆医科大学学报,2007(12):1311-1313.

ZHA NG Sihan et, al. The effect of yemazhui on concentration of levofloxacin in rinse solution of mice tracheae. [J]. Journal of Chongqing Medical University (12):1311-1313(2007)
[1]张斯汉,周远大,何海霞.野马追对小鼠气管冲洗液中左氧氟沙星浓度的影响[J].重庆医科大学学报,2007(12):1311-1313. DOI： 10.13406/j.cnki.cyxb.2007.12.035.

ZHA NG Sihan et, al. The effect of yemazhui on concentration of levofloxacin in rinse solution of mice tracheae. [J]. Journal of Chongqing Medical University (12):1311-1313(2007) DOI： 10.13406/j.cnki.cyxb.2007.12.035.

摘要

目的:探讨野马追对小鼠气管冲洗液中左氧氟沙星浓度的影响。方法:50只小鼠随机分为空白、氯化铵、野马追大、中、小剂量组

每组10只

分别给予生理盐水30ml/kg、氯化铵1.00g/kg、野马追大剂量64.45g（生药）/kg、中剂量32.73g（生药）/kg、小剂量16.36g（生药）/kg后1h

各组动物腹腔注射左氧氟沙星0.07g/kg

2h后处死动物

收集小鼠气管冲洗液

高效液相色谱检测其中左氧氟沙星浓度。结果:野马追大、中、小剂量组小鼠气管冲洗液中的左氧氟沙星浓度分别约为空白组小鼠的4.58、3.18、1.86倍。结论:野马追能提高小鼠气管冲洗液中左氧氟沙星的浓度。

Abstract

Objective:To study the effect of yemazhui on concentration of levofloxacin in rinse solution of mice tracheae. Methods:50 mice were randomly divided into blank group、anwhlor group、yemazhui large-dose group、yemazhui middle-dose group

yemazhui low-dose group

each group had 10 mice. After administration of liquor natrii chloridi isotonicus (NS) 30 ml/10kg

amchlor1.00g/kg、yemazhui large dose 64.45g (curde drug)/kg、yemazhui middle dose 32.73g (curde drug)/kg

yemazhui low dose16.36g(curde drug)/kg

mice were intraperitoneal injected levofloxaein at dosage of 0.07g/kg 2hours after administration. The concentration of levofloxacin in excretion of mice tracheae was detected by HPLC. Results:Comparion with blank group

concentration of levofloxacin in excretion of mice tracheae of yemazhui large-dose group、yemazhui middle-dose group、yemazhui low-dose group was 4.58 times、3.18 times、1.86 times the amout of that. Conclusion:Yemazhui can enhance concentration of lwvofloxacin in rinse solution of mice tracheae.

关键词

野马追左氧氟沙星小鼠气管浓度

Keywords

YemazhuLevofloxacinmiceTunica mucosa tracheaeConcentration

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