Expression of HOXa-10 gene in endometrium mice during early pregnancy

JIA Yongcun; et al

doi:10.13406/j.cnki.cyxb.2007.12.013

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Expression of HOXa-10 gene in endometrium mice during early pregnancy

更新时间：2024-01-17

- Expression of HOXa-10 gene in endometrium mice during early pregnancy
- Journal of Chongqing Medical University Issue 12, Pages: 1260-1264(2007)
- 作者机构：
  
  1. 重庆医科大学公共卫学院生殖生物学研究室
  2. 重庆市渝中区人口和计划生育生殖健康中心
  3. 重庆医科大学公共卫生学院生殖生物学研究室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2007.12.013
  CLC： R714
- Published：2007，
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[1]贾咏存,周生建,魏莎莉,杨戎,陈晓玲,李南.HOXa-10在早孕小鼠子宫内膜中的表达[J].重庆医科大学学报,2007(12):1260-1264.

JIA Yongcun, et al. Expression of HOXa-10 gene in endometrium mice during early pregnancy. [J]. Journal of Chongqing Medical University (12):1260-1264(2007)
[1]贾咏存,周生建,魏莎莉,杨戎,陈晓玲,李南.HOXa-10在早孕小鼠子宫内膜中的表达[J].重庆医科大学学报,2007(12):1260-1264. DOI： 10.13406/j.cnki.cyxb.2007.12.013.

JIA Yongcun, et al. Expression of HOXa-10 gene in endometrium mice during early pregnancy. [J]. Journal of Chongqing Medical University (12):1260-1264(2007) DOI： 10.13406/j.cnki.cyxb.2007.12.013.

摘要

目的:探讨HOXa-10基因在小鼠胚胎着床过程中的作用。方法:分别应用FQ-PCR和免疫组化方法检测未孕及早孕第1、2、3、4、5、7天小鼠子宫内膜HOXa-10基因及蛋白的表达。结果:FQ-PCR测得随着小鼠妊娠天数的增加

子宫内膜HOXa-10基因表达量也逐渐增高

在孕4天达到峰值免疫组化分析显示HOXa-10蛋白在子宫内膜的表达规律与FQ-PCR结果一致。结论:在小鼠胚胎着床过程中

HOXa-10在子宫内膜中高表达

可能对子宫内膜容受性变化有重要的调节作用。

Abstract

Objective:To investigate the effect of HOXa-10 gene in the mouse uterus during embryo implantation. Method: real-time fluorescence quantitative PCR (FQ-PCR) and immunohistochemistry were used to detect the HOXa-10 gene and protein of the mouse of un-pregnant pregnant d1

d5 and d7. Result:The HOXa-10 mRNA/β-actin mRNA expression in pregnant group is higher than that of non-pregnant grnup

and the results showed gradual hoist trend as days past

the HOXa-10 mRNA expression reached the maximum at pregnant d4. Immunohistochemical analysis showed the same results as FQ-PCR. Conclusion:HOXa-10 is persistently expressed in mouse endometrium during the early pregnancy and maybe participates in the regulation process of mouse blastodyst implantation.

关键词

HOXa-10胚胎着床实时荧光定量PCR免疫组织化学

Keywords

HOXa-10Blastocyst implantationHeal-time fluorescence quantitative PCRimmunohistochemical

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