A elevated level of plasma reistin and microinflammation in maintenance hemodialysis patient

ZHONG Ling; et al

doi:10.13406/j.cnki.cyxb.2007.12.005

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A elevated level of plasma reistin and microinflammation in maintenance hemodialysis patient

更新时间：2024-01-17

- A elevated level of plasma reistin and microinflammation in maintenance hemodialysis patient
- Journal of Chongqing Medical University Issue 12, Pages: 1297-1300(2007)
- 作者机构：
  
  1. 重庆医科大学附属第二医院肾内科
  2. 重庆医科大学附属第二医院肾内科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2007.12.005
  CLC： R459.5
- Published：2007，
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[1]钟玲,刘玲,冯利平,雷建蓉,张玲.维持性血透患者高抵抗素血症及其意义探讨[J].重庆医科大学学报,2007(12):1297-1300.

ZHONG Ling, et al. A elevated level of plasma reistin and microinflammation in maintenance hemodialysis patient. [J]. Journal of Chongqing Medical University (12):1297-1300(2007)
[1]钟玲,刘玲,冯利平,雷建蓉,张玲.维持性血透患者高抵抗素血症及其意义探讨[J].重庆医科大学学报,2007(12):1297-1300. DOI： 10.13406/j.cnki.cyxb.2007.12.005.

ZHONG Ling, et al. A elevated level of plasma reistin and microinflammation in maintenance hemodialysis patient. [J]. Journal of Chongqing Medical University (12):1297-1300(2007) DOI： 10.13406/j.cnki.cyxb.2007.12.005.

摘要

目的:观察维持性血透患者血浆抵抗素（Resistin）水平

探讨与微炎症状态的关系。方法:选择我院肾内科病情稳定的维特性血透患者73例

健康志愿者20例

ELISA法测研究对象的空腹IL-6、FNF-α、血抵抗素水平与免疫比浊法测定CRP

并测定血脂、白蛋白、空腹血糖及胰岛素水平

采用空腹血糖×胰岛素/22.5计算胰岛素抵抗（IR）值。结果:维持性血透患者血浆抵抗素水平较正常组明显升高

为（40.15±22.46）ug/L vs（11.78±6.29）ug/L（P<0.01）

同时CRP、IL-6、FNF-α也较正常组明显升高

分别为（4.56±1.46）mg/L vs （2.10±0.67）mg/L（P<0.01）

（90.19±32.04）ng/L vs （49.30±28.12）mg/L（P<0.01）

（115.16±90.35）mg/L vs（48.21±36.54）ng/L（P<0.01）

Spearmen相关分析显示抵抗素与TG、CRP呈正相关（r=0.271

0.246

P<0.05）。结论:维持性血透患者抵抗素水平明显升高且与微炎症状态有关

抵抗素可能在ESRD患者心血管损伤中起作用。

Abstract

Objective:To investigate plasma resistin lever in maintenance hemodialysis(MHD)patients and explore its relationship with micruinflammation. Methods:73 patients with MHD and 20 heahhy volunteers were involved in this study. Plasma concentrations of IL-6

TNF-α

resistin were measured by enzyme linked immunoassay(ELISA). The serum levels of high sensitivity C-reactive protein (CRP)

triglyceride

cholesterol

albumin

glucose and insulin were also detected. The homeostasis model assessment index(HOMA-R) was calculated as an estimate of insulin resistance from the fasting glucose and insulin. Results:The plasma lever of resistin in MHD was significantly increased compared with healthy controls(40.15±22.46 vs 11.78±6.29 ug/L

P<0.01). The levels of CRP

IL-6

TNF-αwere also significantly higher in MHD as compared with heahhy control(4.56±1.46 vs 2.10±0.67 mg/L

P<0.01; 90.19±32.04 vs 49.30±28.12 ng/l

P<0.01; 115.16±90.35 vs 48.21±36.54 ng/L

P<0.01;respectively). A significant positive correlation was observed between the serum resistin and CRP (r=0.246

P<0.05). However plasma resistin levels were not correlated with the levels of IR. Conclusions:The level of resistin in MHD is significant higher compared with heahhv controls and correlated with microinflammation. Resistin is probahly playing important effect on the cardiovascular injury of end stage renal disease.

关键词

维持性血透抵抗素微炎症

Keywords

Maintenance hemodialysisresistinMicroinflammation

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