Analysis of erythrocin induced clindamycin-resistance in Staphylococci

CHEN Ying; et al

doi:10.13406/j.cnki.cyxb.2007.12.004

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Analysis of erythrocin induced clindamycin-resistance in Staphylococci

更新时间：2024-01-17

- Analysis of erythrocin induced clindamycin-resistance in Staphylococci
- Journal of Chongqing Medical University Issue 12, Pages: 1282-1284(2007)
- 作者机构：
  
  1. 中南大学湘雅三医院检验科
  2. 中南大学湘雅三医院检验科,长沙,410013
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2007.12.004
  CLC： R446.5
- Published：2007，
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[1]陈颖,宋明胜,周建党,李翔,漆涌.葡萄球菌对克林霉素诱导性耐药的检测及耐药性分析[J].重庆医科大学学报,2007(12):1282-1284.

CHEN Ying, et al. Analysis of erythrocin induced clindamycin-resistance in Staphylococci. [J]. Journal of Chongqing Medical University (12):1282-1284(2007)
[1]陈颖,宋明胜,周建党,李翔,漆涌.葡萄球菌对克林霉素诱导性耐药的检测及耐药性分析[J].重庆医科大学学报,2007(12):1282-1284. DOI： 10.13406/j.cnki.cyxb.2007.12.004.

CHEN Ying, et al. Analysis of erythrocin induced clindamycin-resistance in Staphylococci. [J]. Journal of Chongqing Medical University (12):1282-1284(2007) DOI： 10.13406/j.cnki.cyxb.2007.12.004.

摘要

目的:了解我院葡萄球菌对克林霉素诱导性耐药的检出率及耐药性情况

指导临床合理用药。方法:按美国国家临床实验室标准化研究所（CLSI/NCCLS）2004年推荐的D试验检测红霉素对克林霉素诱导耐药的葡萄球菌

同时检测耐甲氧西林葡萄球菌（MRS）和甲氧西林敏感葡萄球菌（MSS）对12种常用抗生素的耐药性。结果:310株临床分离葡萄球菌中

红霉素耐药而克林霉素敏感的菌株中D试验阳性的MRS、MSS分别为6.6%（12/183）、18.1%（23/127）

MSS菌株明显高于MRS菌株的检出率

具有统计学意义（x

=9.99

0.01）。51株红霉素耐药、克林霉素敏感的葡萄球菌中

D试验阳性菌株35株

检出率为68.6%（35/51）。对于12种常用抗生素的耐药性除复方新诺明和万古霉素外

MRS对其余10种抗生素的耐药率明显高于MSS

具有统计学意义（P

0.01）。结论:常规开展D试验检测红霉素对克林霉素诱导耐药的葡萄球菌

D试验阳性应报告分离株对克林霉素耐药

可避免不适当使用克林霉素导致临床上的治疗失败

有助于医生正确选用大环内酯类及林可霉素类抗生素;并且MRS的耐药性较高

对各类抗生素多重耐药

需加强其耐药性监测。

Abstract

Objective:To investigate the frequency and antihiotic-resistance of inducible-clindamycin-resistant Staphylococci for rational prescription of antibioties. Methods:Erythromycin-inducible-Clindamycin-resislant staphylococci were detected by using D test recommended by Clinical Laboratory Standard Institution(CLSI/NCCLS)

and the resistance of meihicillin-resisiant Staphylococcus and Methicillin-sensitive Staphylococcus to 12 kinds of antibioties were detected. Results:Among 310 strains of Staphylococci

in strains of erythromycin-resistani-and-clindamyein-sensitive Staphylococci

the percentage of MRS with positive D test was 6.6%(12/183)

and that of MSS was 18.1%(23/127). There is significant difference between them(x~2=9.99

P<0.01). Of 51 strains of erythromycin-resistant-clindamycin-sensitive Staphylococci

68.6%(35/51)showed positive D test resuhs. Except for cotrimoxazole and vancomycin

the resistance of MRS to the other 10 antibiotics was much higher than that of MSS

and the difference is significant(P<0.01). Conclusions:D test can be used for detection of erythromyein-inducible-clindamycin-resistant Staphylococci

and strains with positive D test results show resistance to clindamycin

which will guide rational prescription of antibiotics

such as macrolides and lincomycin.

关键词

葡萄球菌红霉素克林霉素诱导性耐药耐药性分析

Keywords

StaphylococcierythromycinClindamycinInducihle resistanceAnalysis of drug-resistance

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