Objective:To evaluate the clinical value of radionuclide imaging with

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I-MIBG in the diagnosis of adrenal medullary lesions.Methods:The

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I-MIBG adrenal medullary imaging results of 48 patients（12 with primary hypertension as control group

21 with pheochromocytoma

and 15 with adrenal medullary hyperplasia）were analyzed and compared with those of CT and B ultrasonography.The uptake ratio of adrenal gland to background and to myocardium were calculated and compared by ROI sequence.Results:In

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I-MIBG imaging

for the patients with pheochromocytoma

11 of them were found abnormal radioac- tive increase of one adrenal gland;2 ectopic pheochromocytoma were demonstrated;3 were found with multiple abnormal ra- dioactive increase in the whole body besides adrenal gland were demonstrated with malignant pheochromoeytoma;one adrenal gland was shown clearly of 3 patients and 2 patients appeared negative

with the positive rate of 90.5%.Of the patients with adrenal medullary hyperplasia

8 were found with one adrenal gland imaging and 3 with two adrenal gland imaging;4 patients appeared with negative

with the positive rate of 73.3%.The uptake ratio（obtained by ROI sequence）in pheochromocytoma and hyperplasia group were remarkably higher than that in control group

of which pheochromocytoma group was remarkably higher than hyperplasia group.Conclusion:

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I-MIBG imaging is an effective tool in the localizing and qualitative diagnosis of adrenal medullary lesions.ROI sequence can increase the positive rate and benefit the differential diagnosis.