Expression of sunvivin and p53 in cervical carcinoma and its clinical significance

GAN Xiaoqin

doi:10.13406/j.cnki.cyxb.2007.07.026

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Expression of sunvivin and p53 in cervical carcinoma and its clinical significance

更新时间：2024-01-17

- Expression of sunvivin and p53 in cervical carcinoma and its clinical significance
- Journal of Chongqing Medical University Issue 7, Pages: 702-704(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院妇产科
  2. 重庆医科大学附属第一医院妇产科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2007.07.026
  CLC： R737.33
- Published：2007，
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[1]干晓琴,赵纯全,姬立芹.宫颈鳞癌组织中Survivin和p53蛋白的表达及其临床意义[J].重庆医科大学学报,2007(07):702-704+730.

GAN Xiaoqin. Expression of sunvivin and p53 in cervical carcinoma and its clinical significance. [J]. Journal of Chongqing Medical University (7):702-704(2007)
[1]干晓琴,赵纯全,姬立芹.宫颈鳞癌组织中Survivin和p53蛋白的表达及其临床意义[J].重庆医科大学学报,2007(07):702-704+730. DOI： 10.13406/j.cnki.cyxb.2007.07.026.

GAN Xiaoqin. Expression of sunvivin and p53 in cervical carcinoma and its clinical significance. [J]. Journal of Chongqing Medical University (7):702-704(2007) DOI： 10.13406/j.cnki.cyxb.2007.07.026.

摘要

目的:探讨宫颈鳞癌组织中Survivin和p53蛋白的表达及其临床意义。方法:采用免疫组化SP法检测60例宫颈鳞癌组织中Survivin和p53蛋白的表达情况

并结合临床病理特征进行分析。结果:Survivin和p53在宫颈鳞癌中的表达阳性率分别为90%、53.33%。Survivin的表达与患者的年龄、分化程度、新辅助化疗及有无淋巴结转移无关

但与临床分期显著相关。p53蛋白的表达与患者的年龄、分化程度无关

但与临床分期、是否进行新辅助化疗及有无淋巴结转移显著相关。Survivin和p53在宫颈鳞癌中共同表达阳性率为51.67%

尤其是术前进行了新辅助化疗或伴转移的病例中

二者的共同表达阳性率更高

分别为85%和91.67%。结论:Survivin和p53可能参与了宫颈癌的演进和恶化

两者可能起协同作用。

Abstract

Objective:To investigate the clinical significance of the expression of Survivin and p53 in cervical carcinoma.Meth- ods:Expression of Survivin and p53 in sixty paraffin-embedded specimens of cervical carcinoma patients were examined by us- ing the immunohistochemistry method.Results:The positive expressions rates of Survivin and p53 in sixty cervical carcinoma specimens were 90%

53.33% respectively.The positive expressions of Survivin were not associated with age

differentiation grade

neoadjuvant chemotherapy and lymph node metastasis

but were highly associated with clinical stage.The positive expres- sions of p53 were not associated with age and differentiation grade

but highly associated with clinical stage

neoadjuvant chemotherapy and lymph node metastasis.The positive rate of the co-expression of Survivin and p53 in sixty specimens was 51.67%

and it was especially higher in the patients who experienced neoadjuvant chemotherapy(85%)or had lymph node metastasis(91.67%).Conclusions:The expressions of Survivin and p53 in cervical carcinoma might cooperatively play an im- portant role in the progression and deterioration of cervical carcinoma.

关键词

宫颈鳞癌/病理学基因表达免疫组化

Keywords

Cervical cancinoma/pathologygene expressionimmunohistochemistry

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