Expression and clinical significance of Livin in benign prostate hyperplasia and prostate cancer

LI Jiabing

doi:10.13406/j.cnki.cyxb.2007.07.025

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Expression and clinical significance of Livin in benign prostate hyperplasia and prostate cancer

更新时间：2024-01-17

- Expression and clinical significance of Livin in benign prostate hyperplasia and prostate cancer
- Journal of Chongqing Medical University Issue 7, Pages: 689-691(2007)
- 作者机构：
  
  1. 四川省绵阳市第三人民医院泌尿外科
  2. 四川省绵阳市第三人民医院
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2007.07.025
  CLC： R697.3;R737.25
- Published：2007，
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[1]李家兵,李锦秀,姚惠.凋亡抑制蛋白Livin在良性前列腺增生和前列腺癌中的表达及临床意义[J].重庆医科大学学报,2007(07):689-691+717.

LI Jiabing. Expression and clinical significance of Livin in benign prostate hyperplasia and prostate cancer. [J]. Journal of Chongqing Medical University (7):689-691(2007)
[1]李家兵,李锦秀,姚惠.凋亡抑制蛋白Livin在良性前列腺增生和前列腺癌中的表达及临床意义[J].重庆医科大学学报,2007(07):689-691+717. DOI： 10.13406/j.cnki.cyxb.2007.07.025.

LI Jiabing. Expression and clinical significance of Livin in benign prostate hyperplasia and prostate cancer. [J]. Journal of Chongqing Medical University (7):689-691(2007) DOI： 10.13406/j.cnki.cyxb.2007.07.025.

摘要

目的:探讨凋亡抑制蛋白（Inhibitor of apoptosis protein IAP）家族的新成员Livin及其两种异构体Livinα和Livinβ在良性前列腺增生和前列腺癌组织中的表达

及其与前列腺癌发生发展的关系。方法:采用逆转录聚合酶链反应（RT-PCR）法检测26例前列腺癌、20例良性前列腺增生和10例正常前列腺组织中Livinα和Livinβ的表达。结果:26例前列腺癌组织中Livinα表达阳性率为65.38%

20例良性前列腺增生组织中阳性表达率为60.00%

而在正常前列腺组织中均不表达

Livinβ在前列腺癌组织及良性前列腺增生和正常前列腺组织中均不表达。Livinα在正常前列腺组织中的表达率与在前列腺癌、良性前列腺增生中的阳性表达率有显著差异

而在良性前列腺增生和前列腺癌中的阳性表达率无显著差异

同时Livinα的表达与前列腺癌的病理分级和临床分期均无明显相关关系。结论:Livinα在前列腺癌和良性前列腺增生中的高表达及与前列腺癌和良性前列腺增生的发生、发展密切相关。

Abstract

Objective:To examine and analyze the expression of two isoforms of Livin(Livinαand Livinβ)

a novel inhibitor of apoptosis protein(IAP)family member in benign prostate hyperplasia(BPH)and prostate cancer(PC)

and to explore relationship between Livin expression and prostate cancer.Methods:Livin mRNA in BPH

PC and normal protate tissue(NP)were detected by reverse transcription polymerase chain reaction(RT-PCR).Results:LivinαmRNA was expressed in 17 of 26 PC cases(65.38%) and in 12 of 20 BPH cases(60.00%)

No Livinαexpression was detected in NP

Livinβwas not detected in BPH

PC and NP.The Livinαpositive expression ratios had significant differences(P<0.05)between NP and BPH or PC

No significant differ- ence of Livinαpositive expression ratio was found between BPH and PC(P>0.05).There was no relationship(P>0.05)between the Livinαexpression and histologic grade or clinical stage of PC.Conclusion:Livinαis highly expressed in PC and BPH

which may play an important role in generation and progression of PC and BPH

关键词

良性前列腺增生前列腺腺癌livinRT-PCR

Keywords

benign prostate hyperplasiaProstate cancerlivinRT-PCR

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