Effect of ovariectomy on learning and memory in aged rats

TANG Mingshan

doi:10.13406/j.cnki.cyxb.2007.07.021

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Effect of ovariectomy on learning and memory in aged rats

更新时间：2024-01-17

- Effect of ovariectomy on learning and memory in aged rats
- Journal of Chongqing Medical University Issue 7, Pages: 699-701(2007)
- 作者机构：
  
  1. 重庆市第一人民医院神经内科
  2. 重庆市第一人民医院神经内科,重庆,400011
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2007.07.021
  CLC： R713
- Published：2007，
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[1]唐明山,黄开斌,甘碧坤,卢伟,翁旭,钟华.卵巢切除术对老龄大鼠学习记忆功能的影响[J].重庆医科大学学报,2007(07):699-701+784.

TANG Mingshan. Effect of ovariectomy on learning and memory in aged rats. [J]. Journal of Chongqing Medical University (7):699-701(2007)
[1]唐明山,黄开斌,甘碧坤,卢伟,翁旭,钟华.卵巢切除术对老龄大鼠学习记忆功能的影响[J].重庆医科大学学报,2007(07):699-701+784. DOI： 10.13406/j.cnki.cyxb.2007.07.021.

TANG Mingshan. Effect of ovariectomy on learning and memory in aged rats. [J]. Journal of Chongqing Medical University (7):699-701(2007) DOI： 10.13406/j.cnki.cyxb.2007.07.021.

摘要

目的:探讨卵巢切除术对老龄大鼠学习记忆功能的影响。方法:17月龄停止繁殖2个周期的SD大鼠

体重350～400g分为正常对照组、假手术组和卵巢切除组。术后第1天、3天、7天、15天、30天

采用Morris水迷宫实验检测大鼠学习记忆功能。结果:术后第30天

3组大鼠结果无显著差异（P>0.05）;与假手术组大鼠相比

卵巢切除组大鼠在各时相点的所有结果均无显著差异（P>0.05）。与正常对照组大鼠相比

卵巢切除组大鼠和假手术组大鼠的潜伏期在术后第1天、3天、7天较长（P<0.01

P<0.05）

在平台象限游泳路径百分比在术后1天、3天、7天较少（P<0.05）。穿越原平台象限的次数在术后1天、3天、7天、15天较少（P<0.01

P<0.05）。结论:腹部手术可损害老龄大鼠学习记忆功能

这种损害可在术后30天内恢复

单纯卵巢切除并不加重手术引起的大鼠学习记忆功能损害。

Abstract

Objective:To investigate the effect of ovariectomy on cognition of aged rats.Methods:Sprague-Dawley rats retired from breeding for two reproductive cycles

17-month-old

and 350-400g weight

were divided into three groups.After being operated for 1d

15d and 30d

the rats were tested by Morris water maze to observe the function of learning and mem- ory.Results:There were no differential result between the rats of the three groups in 30d(P>0.05)

and there was no differen- tial result too between the rats of variectomized group and sham operated group in each stage of the full test(P>0.05).Com- pared with the control group

the rats of ovarietomized group and sham operated group showed more escape latency for 1d

Td(P<0.01

P<0.05)

less percentage of swimming length in platform quadrant for 1d

7d(P<0.05)

and less frequency of passing through origin platform quadrant for 1d

15d(P<0.01

P<0.05).Conclusion:Abdominal operation may damage the function of learning and memory

but they will be recovery after 30 days

Simple ovariectomy don’t aggravate more.

关键词

卵巢切除术大鼠学习记忆

Keywords

Ovariectomyratlearning and memory

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