Expression level of MMP10 in human spontaneous abortion deciduas and its clinical significance

YU Qiubo

doi:10.13406/j.cnki.cyxb.2007.07.019

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Expression level of MMP10 in human spontaneous abortion deciduas and its clinical significance

更新时间：2024-01-17

- Expression level of MMP10 in human spontaneous abortion deciduas and its clinical significance
- Journal of Chongqing Medical University Issue 7, Pages: 679-681(2007)
- 作者机构：
  
  1. 重庆医科大学生殖生物学研究室公共卫生学院遗传优生教研室
  2. ,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2007.07.019
  CLC： R714.21
- Published：2007，
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[1]余秋波,李红梅,董艳玲,王应雄,何俊琳.自然流产患者蜕膜MMP10的表达及临床意义[J].重庆医科大学学报,2007(07):679-681+781.

YU Qiubo. Expression level of MMP10 in human spontaneous abortion deciduas and its clinical significance. [J]. Journal of Chongqing Medical University (7):679-681(2007)
[1]余秋波,李红梅,董艳玲,王应雄,何俊琳.自然流产患者蜕膜MMP10的表达及临床意义[J].重庆医科大学学报,2007(07):679-681+781. DOI： 10.13406/j.cnki.cyxb.2007.07.019.

YU Qiubo. Expression level of MMP10 in human spontaneous abortion deciduas and its clinical significance. [J]. Journal of Chongqing Medical University (7):679-681(2007) DOI： 10.13406/j.cnki.cyxb.2007.07.019.

摘要

目的:探讨基质金属蛋白酶10（MMP10）基因及其蛋白在人自然流产蜕膜中的表达水平及临床意义。方法:利用RT-PCR和Western blotting技术分别检测MMP10基因和蛋白在人正常蜕膜和自然流产蜕膜的表达水平、利用免疫组织化学技术检测MMP10在人正常蜕膜和自然流产蜕膜组织中的分布。结果:正常蜕膜中MMP10基因（0.20±0.08）及蛋白（0.25±0.07）表达均较低

在自然流产蜕膜中MMP10基因（0.65±0.10）及蛋白（0.79±0.10）表达均较高

两者差异具有显著性意义（P<0.01）;MMP10主要表达在流产蜕膜的基质细胞。结论:MMP10在流产蜕膜中高表达可能有利于降解细胞外基质

促进胚胎滋养细胞的侵袭

从而延缓自然流产。

Abstract

Objective:To discuss expression levels of MMP10 gene and protein in human spontaneous abortion deciduas and its significance in clinic.Methods:Expression levels of MMP10 gene and protein in human spontaneous abortion decidua were determined by RT-PCR

Western blotting and distribution by immunohistochemistry.Results:Expression levels of MMP10 mRNA and protein in all normal deciduas were lower(0.20±0.08

0.25±0.07)

but all increased in Spontaneous Abortion Deciduas(0.65±0.10

0.79±0.10).The difference between the two groups was significant(P<0.01

MMP10 was mainly expressed in stromal cells.Conclusion:The results suggested that higher expression of MMP10 in spontaneous abortion deciduas might resolve the matrix metalloproteinase

promote the extrovillous cytocyst cells invasion and prohibit the spontaneous abortion.

关键词

基质金属蛋白酶10自然流产蜕膜

Keywords

Protein of matrix metalloproteinase10spontaneous abortionDecidua

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Related Institution

Department of Genetics, Chongqing Medical University

重庆医科大学遗传优生教研室

Department of Genetic,Colledge of Public Health,Chongqing Medical University

重庆医科大学公共卫生学院遗传优生教研室

Teaching and Research Section of Reproductive Biology，College of Public Health and Management，Chongqing Medical University

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