Impact of intravenous immunoglobulin on the panel reactive antibody in renal transplantation

LIANG Simin

doi:10.13406/j.cnki.cyxb.2007.07.018

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Impact of intravenous immunoglobulin on the panel reactive antibody in renal transplantation

更新时间：2024-01-17

- Impact of intravenous immunoglobulin on the panel reactive antibody in renal transplantation
- Journal of Chongqing Medical University Issue 7, Pages: 743-745(2007)
- 作者机构：
  
  1. 重庆医科大学附属第一医院肾移植中心
  2. 重庆医科大学附属第一医院肾移植中心,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2007.07.018
  CLC： R699
- Published：2007，
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[1]梁思敏,吴小候,尹志康,刘航.静脉滴注免疫球蛋白对肾移植患者群体反应抗体的影响[J].重庆医科大学学报,2007(07):743-745.

LIANG Simin. Impact of intravenous immunoglobulin on the panel reactive antibody in renal transplantation. [J]. Journal of Chongqing Medical University (7):743-745(2007)
[1]梁思敏,吴小候,尹志康,刘航.静脉滴注免疫球蛋白对肾移植患者群体反应抗体的影响[J].重庆医科大学学报,2007(07):743-745. DOI： 10.13406/j.cnki.cyxb.2007.07.018.

LIANG Simin. Impact of intravenous immunoglobulin on the panel reactive antibody in renal transplantation. [J]. Journal of Chongqing Medical University (7):743-745(2007) DOI： 10.13406/j.cnki.cyxb.2007.07.018.

摘要

目的:研究静脉滴注免疫球蛋白（Intravenous immunoglobulin

IVIG）对肾移植患者群体反应抗体（Panel reactive anti- body

PRA）作用及治疗效果。方法:57例等待肾脏移植的PRA致敏患者

年龄21～65岁

PRA值为35%～91%

平均为46.7%±29.5%。采用静脉滴注IVIG 5g/d

两周为1个疗程。两个疗程之间

间隔1周时间。用药开始前检测1次PRA

疗程结束立即冉检测1次PRA。结果:57例中有36例患者（63.2%）用药1个疗程

15例患者（26.3%）用药2个疗程

6例患者（10.5%）用药3个疗程。应用免疫球蛋白后PRA降为非致敏48例（84.2%）

完全未降3例（5.2%）

部分下降6例（10.6%）。用药后PRA下降0～61%（平均38.4%±16.3%）

与用药前比较差异显著（P<0.01）。57例患者均进行肾脏移植手术

术前淋巴细胞毒试验（CDC）<10%

均未出现超急性排斥反应。2例患者（3.5%）术后发生急性排斥反应（AR）

加用MP及FK506治疗后

急性排斥逆转

肾功能逐渐恢复正常。结论:IVIG能有效降低高敏肾移植患者的PRA值

提高肾移植的成功率。

Abstract

Objective:To investigate the effect of intravenous immunoglobulin(IVIG)on the panel reactive antibody(PRA)in renal transplantation.Methods:57 highly sensitized patients awaiting renal transplantation

age 21 to 65 years

the value of PRA were 35% to 91%(mean46.7%±29.5%).All received the treatment by IVIG 5g/d

gtt

period of treatment was 2 weeks.We ex- amined the value of PRA before treatment and after treatment of IVIG.Results:36 patients used one period of treatment

15 patients used two period of treatment

6 patients used three period of treatment.After treatment of IVIG

the value of PRA de- creased to non-sensitivity in 48 patients

completely no decreased in 3 patients

partly decreased in 6 patients.The patients re- sulted in reduction in PRA of 0～61%(mean decrease:38.4%±16.3%)

there were significant difference in patients with treat- ment of IVIG.All patients received renal transplantation which CDC less than 10%

there were no hyperacute rejection ap- pearance.After operation

there were 2 patients(3.5%)occurred acute rejection and treated with MP plus FK506

the renal function returned normal gradually.Conclusion:Intravenous injection of high dose of IVIG could reduce the value of PRA in some highly sensitized patients and could increased the rate of succeed in renal transplantation.

关键词

肾移植群体反应抗体免疫球蛋白

Keywords

renal transplantationPanel reactive antibodyIntravenous immunoglobulin

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