Empirical study of furazolidone-induced dilated cardiomyopathy model in rats

DING Le

doi:10.13406/j.cnki.cyxb.2007.07.009

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Empirical study of furazolidone-induced dilated cardiomyopathy model in rats

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- Empirical study of furazolidone-induced dilated cardiomyopathy model in rats
- Journal of Chongqing Medical University Issue 7, Pages: 718-721(2007)
- 作者机构：
  
  1. 重庆医科大学附属儿童医院心血管内科
  2. 重庆医科大学附属儿童医院心脏彩超声室
  3. 重庆医科大学附属儿童医院儿科研究所
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2007.07.009
  CLC： R542.2
- Published：2007，
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[1]丁乐,钟家蓉,白永虹,张小萍.呋喃唑酮诱导大鼠扩张性心肌病模型的实验研究[J].重庆医科大学学报,2007(07):718-721.

DING Le. Empirical study of furazolidone-induced dilated cardiomyopathy model in rats. [J]. Journal of Chongqing Medical University (7):718-721(2007)
[1]丁乐,钟家蓉,白永虹,张小萍.呋喃唑酮诱导大鼠扩张性心肌病模型的实验研究[J].重庆医科大学学报,2007(07):718-721. DOI： 10.13406/j.cnki.cyxb.2007.07.009.

DING Le. Empirical study of furazolidone-induced dilated cardiomyopathy model in rats. [J]. Journal of Chongqing Medical University (7):718-721(2007) DOI： 10.13406/j.cnki.cyxb.2007.07.009.

摘要

目的:应用呋喃唑酮诱导大鼠扩张性心肌病（DCM）模型的建立。方法:用呋喃唑酮长期喂饲Wistar大鼠建立扩张性心肌病模型

超声心动图检测大鼠左室舒张末内径（LVDD）、左室收缩末内径（LVSD）、左室舒张末容积（LVDV）、左室收缩末容积（LVSV）、左室内径缩短率（FS）及左室射血分数（INEF）

病理组织切片检查心肌的形态学变化。结果:与正常对照组相比

DCM组大鼠体重明显减轻

心脏重量/体重比值增加

心脏呈球形扩大

LVSD明显增大

FS（%）和LVEF（%）均明显下降。HE和VG染色分别显示DCM组大鼠心肌细胞肥大、变性

间质胶原纤维明显增多。结论:呋喃唑酮长期喂养可成功建立大鼠扩张型心肌病模型

方法简单

死亡率低

成功率高。经胸超声心动图可以用来检测评估模型的建立和效果。

Abstract

Objective:To determine the efficacy and reliability of furozolidone-induced dilated cardiomyopathy model in rats and to evaluate it by transthoracic echocardiography.Methods:Wistar rats were fed with furazolidone for eight weeks.Left ventricu- lar end-diastolic diameter(LVDD)

left ventricular end-systolic diameter(LVSD)

fraction shortening(FS)and left ventricular e- jection fraction(LVEF)were determined by echocardiogram.Myocardial cell morphology was observed by histopathologic slides. Results:Compared with the normal control group

the body weights

FS and LVEF were decreased obviously

whereas the ra- tios of heart weight and body weight and LVSD were increased significantly.The HE and VG staining displayed that Myocardial cells developed hypertrophy and degeneration

whereas the interstitial collagen fibers got hyperplasia.Conclusion: The DCM rats model can be established successfully hy feeding with furozolidone for long time.This method is simple with high success rate and low death rate.The transthoracic echocardiography can be applied in monitoring the animal model’s formation and effect.

关键词

扩张性心肌病呋喃唑酮超声心动图大鼠动物模型

Keywords

Dilated cardiomyopathyFurozolidoneechocardiographyratanimal model

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