Experimental study on general pharmacological actions of bencycloquidium bromide

doi:10.13406/j.cnki.cyxb.2007.05.034

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Experimental study on general pharmacological actions of bencycloquidium bromide

更新时间：2024-01-17

- Experimental study on general pharmacological actions of bencycloquidium bromide
- Journal of Chongqing Medical University Issue 5, Pages: 506-510(2007)
- 作者机构：
  
  重庆医科大学附属第一医院临床药理研究室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2007.05.034
  CLC： R96
- Published：2007，
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[1]李娟,周远大.苯环喹溴铵的一般药理学研究[J].重庆医科大学学报,2007(05):506-510.

Experimental study on general pharmacological actions of bencycloquidium bromide. [J]. Journal of Chongqing Medical University (5):506-510(2007)
[1]李娟,周远大.苯环喹溴铵的一般药理学研究[J].重庆医科大学学报,2007(05):506-510. DOI： 10.13406/j.cnki.cyxb.2007.05.034.

Experimental study on general pharmacological actions of bencycloquidium bromide. [J]. Journal of Chongqing Medical University (5):506-510(2007) DOI： 10.13406/j.cnki.cyxb.2007.05.034.

摘要

目的:探讨一类新药苯环喹溴铵的一般药理作用。方法:将苯环喹溴铵分为大、中、小剂量鼻粘膜给药后

观察苯环喹溴铵对小鼠精神神经活动、激怒反应、自主活动、支气管腺体分泌和小肠蠕动的作用;并观察对Beagle犬血压、心电图、心率、心律以及呼吸频率和幅度的影响。结果:苯环喹溴铵对动物中枢神经系统有一定的抑制作用（后可缓解）

能减少支气管的腺体分泌

降低小肠的蠕动

但对呼吸频率和幅度以及心血管系统无明显影响。结论:苯环喹溴铵对动物的心血管和呼吸系统无明显影响

但对中枢神经系统有一定抑制作用

并可减少支气管腺体分泌、抑制小肠蠕动。

Abstract

Objective:To study the general pharmacological actions of bencycloquidium bromide.Methods:Bencycloquidium bro- mide was administered through nasal mucosa in high

medium and low doses to mice and beagle dogs.The psycho-nervous action

enraging response

voluntary movement

bronchus gland excretion

small intestine peristalsis of mice were observed

and the cardiovascular and respiratory reactions of beagle dogs were detected.Results:Bencycloquidium bromide had no obvious effect on cardiovascular and respiratory systems of beagle dogs;but it had inhibitory action on central nerve system of mice which can be relieved later.It could also decrease the excretion of bronchus gland and the peristalsis of small intestine.Conclusion:Bencycloquidium bromide had no obvious effect on cardiovascular system and respiratory system in animals;but had certain inhibitory action on central nerve system

and could decrease the excretion of bronchus gland and inhibit the peristalsis of small intestine in animals.

关键词

苯环喹溴铵中枢神经系统心血管系统呼吸系统腺体小肠

Keywords

Bencycloquidium bromideCentral nerve systemCardiovascular systemRespiratory systemGlandsmall intestine

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南京航空航天大学生物医学工程系,南京航空航天大学生物医学工程系,四川大学水电工程学院,南京航空航天大学生物医学工程系,南京航空航天大学生物医学工程系

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Department of General Surgery,The Frist Affiliated Hospital of Chongqing Medical University

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