Effects of Gypenosides and Ginkgo Bilobal Flavone on proliferation of acute myeloid leukemia cells(HL-60)

doi:10.13406/j.cnki.cyxb.2007.05.024

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Effects of Gypenosides and Ginkgo Bilobal Flavone on proliferation of acute myeloid leukemia cells(HL-60)

更新时间：2024-01-17

- Effects of Gypenosides and Ginkgo Bilobal Flavone on proliferation of acute myeloid leukemia cells(HL-60)
- Journal of Chongqing Medical University Issue 5, Pages: 500-502(2007)
- 作者机构：
  
  1. 重庆医科大学医学检验系临床检验诊断学省部共建教育部重点实验室,重庆市重点实验室
  2. 总装备部重庆军代局门诊部
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2007.05.024
  CLC： R733.7
- Published：2007，
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[1]王箭,阳强,朱旦,王虹,安琳,翁亚光.绞股蓝皂甙与银杏内脂黄酮对HL-60细胞增殖的影响[J].重庆医科大学学报,2007(05):500-502.

Effects of Gypenosides and Ginkgo Bilobal Flavone on proliferation of acute myeloid leukemia cells(HL-60). [J]. Journal of Chongqing Medical University (5):500-502(2007)
[1]王箭,阳强,朱旦,王虹,安琳,翁亚光.绞股蓝皂甙与银杏内脂黄酮对HL-60细胞增殖的影响[J].重庆医科大学学报,2007(05):500-502. DOI： 10.13406/j.cnki.cyxb.2007.05.024.

Effects of Gypenosides and Ginkgo Bilobal Flavone on proliferation of acute myeloid leukemia cells(HL-60). [J]. Journal of Chongqing Medical University (5):500-502(2007) DOI： 10.13406/j.cnki.cyxb.2007.05.024.

摘要

目的:探讨并比较绞股蓝皂甙（Gypenosides

GP）与银杏内脂黄酮影响急性髓性白血病（HL-60）细胞增殖的作用。方法:分别以不同浓度绞股蓝皂甙与银杏内脂黄酮

不同作用时间处理HL-60细胞株

用MTT法观察绞股蓝皂甙与银杏内脂黄酮对（HL-60）细胞增殖的影响

流式细胞仪检测细胞增殖周期情况。结果:绞股蓝皂甙与银杏内脂黄酮在0.025～0.8mg/ml终浓度范围内

对HL-60细胞增殖的抑制作用显著

并随药物浓度及作用时间的增加而增强（P

0.05）。两药均可显著减少G

/M+期细胞

增加G

期细胞

并诱导凋亡细胞峰出现。结论:绞股蓝皂甙与银杏内脂黄酮均能显著的影响HL-60细胞增殖

两种药物抑制HL-60细胞增殖的机制与干扰细胞增殖、分裂

诱导凋亡有关。

Abstract

Objective:To investigate and compare the effects of Gypenosides and Ginkgo Bilobal Flavone on acute myeloid leukemia cells（HL-60）.Methods:MTT was used to investigate the proliferation inhibition of HL-60 with different dosages and various action periods of Gypenosides and Ginkgo Bilobal Flavone at a range of final concentrations of 0.025～0.8mg/ml（P

0.05）. Flow cytometry was applied to determine the effects on cell growth cycle.Results:Both of Gypenosides and Ginkgo Bilobal Flavone significantly inhibited the cell number of G

/M+ phase

increase the cell number of G

phase

and induce the apop- tosis of HL-60.Conclusion:Gypenosides and Ginkgo Bilobal Flavone both have notable inhibitory effects on growth of HL-60

and the mechanism involves the inhibition of G

/M+ phase of HL-60 cell growth cycle and the induction of cell apoptosis.

关键词

绞股蓝皂甙银杏内脂黄酮凋亡细胞周期HL-60细胞株

Keywords

GypenosidesGinkgo Bilobal Flavoneapoptosiscell cycleHL-60 cell line

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