Rifaximin in treatment of acute bacterial diarrhea.a randomized,single-blind clinical trial

doi:10.13406/j.cnki.cyxb.2007.05.012

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Rifaximin in treatment of acute bacterial diarrhea.a randomized,single-blind clinical trial

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- Rifaximin in treatment of acute bacterial diarrhea.a randomized,single-blind clinical trial
- Journal of Chongqing Medical University Issue 5, Pages: 531-533(2007)
- 作者机构：
  
  1. 重庆医科大学附属第二医院感染病科
  2. 四川省百利制药有限公司
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2007.05.012
  CLC： R515
- Published：2007，
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[1]凌宁,周智,黄长武,张大志,任红,谭光星.利福昔明片与环丙沙星片随机、单盲对照治疗急性细菌感染性腹泻的临床疗效观察[J].重庆医科大学学报,2007(05):531-533.

Rifaximin in treatment of acute bacterial diarrhea.a randomized,single-blind clinical trial. [J]. Journal of Chongqing Medical University (5):531-533(2007)
[1]凌宁,周智,黄长武,张大志,任红,谭光星.利福昔明片与环丙沙星片随机、单盲对照治疗急性细菌感染性腹泻的临床疗效观察[J].重庆医科大学学报,2007(05):531-533. DOI： 10.13406/j.cnki.cyxb.2007.05.012.

Rifaximin in treatment of acute bacterial diarrhea.a randomized,single-blind clinical trial. [J]. Journal of Chongqing Medical University (5):531-533(2007) DOI： 10.13406/j.cnki.cyxb.2007.05.012.

摘要

目的:评价国产利福昔明治疗细菌感染性腹泻的疗效和安全性。方法:采用随机、单盲对照试验

以国产环丙沙星作对照

研究利福昔明治疗细菌感染性腹泻的效果。利福昔明第1日每次0.4g

1日3次

第2日起每次0.4g

1日2次;环丙沙星第1日每次0.25g

1日3次

第2日起每次0.25g

1日2次

疗程均为3～7天。治疗前后查血、尿、大便常规

肝功、肾功生化和心电图用于安全性评价。结果:利福昔明组29例

环丙沙星组25例

其中35例治疗前分离到病原菌

细菌阳性率为64.8%。临床有效率和临床痊愈率分别为100%和91.3%

两组临床有效率和临床痊愈率无统计学差异。细菌清除率分别为100%和87.5%

亦无统计学差异。两组未观察到不良反应的发生。结论:利福昔明片治疗细菌感染性腹泻的临床疗效肯定

不良反应少

可在细菌感染性腹泻治疗中应用。

Abstract

Objective:To evaluate the efficacy and safety of rifaximin against acute bacterial diarrhea.Methods:The effect of rifaximin for the treatment of acute bacterial diarrhea was investigated in a randomized

single-blind clinical trial with control of ciprofloxacin.Patients were administered with rifaximin 0.4g tid on the first day

followed by 0.4g bid;as for ciprofloxacin 0.25g tid on the first day

followed by 0.25g bid

until the end of 3～7days treatment

respectively.Stool

blood(hepatic and renal functions)

urine samples and ECG of pre-and post-treatment were assayed for safety evaluation of rifaximin in diarrhea patients.Results:29 patients in rifaximin group and 25 in ciprofloxacin group showed similar efficacy rates and recovery rates

100% and 91.3% respectively.There was no statistic difference between the two groups related to the effectiveness.The bacterium positive rate was 64.8%(35/54)before treatment.Bacterial clearance rates were 100% and 87.5%.No statistic difference and obvious side effect in the two groups were observed.Conclusion:rifaximin is safe and effective in the treatment of acute bacterial diarrhea.

关键词

利福昔明环丙沙星感染性腹泻

Keywords

rifaximinCiprofloxacinBacterial diarrhea

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