Study on compatibility of the nHA/PA composite implant

ZHANG Jian; et al

doi:10.13406/j.cnki.cyxb.2005.06.013

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Study on compatibility of the nHA/PA composite implant

更新时间：2024-01-17

- Study on compatibility of the nHA/PA composite implant
- Journal of Chongqing Medical University Issue 6, Pages: 828-830(2005)
- 作者机构：
  
  1. 重庆医科大学附属第一医院骨科
  2. 重庆医科大学附属第一医院骨科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.06.013
  CLC： R318.08
- Published：2005，
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[1]张健,安洪,蒋电明,周爱国.纳米羟基磷灰石／聚酰胺复合材料人工肱骨头的体内生物相容性研究[J].重庆医科大学学报,2005(06):828-830.

ZHANG Jian, et al. Study on compatibility of the nHA/PA composite implant. [J]. Journal of Chongqing Medical University (6):828-830(2005)
[1]张健,安洪,蒋电明,周爱国.纳米羟基磷灰石／聚酰胺复合材料人工肱骨头的体内生物相容性研究[J].重庆医科大学学报,2005(06):828-830. DOI： 10.13406/j.cnki.cyxb.2005.06.013.

ZHANG Jian, et al. Study on compatibility of the nHA/PA composite implant. [J]. Journal of Chongqing Medical University (6):828-830(2005) DOI： 10.13406/j.cnki.cyxb.2005.06.013.

摘要

目的:了解纳米羟基磷灰石／聚酰胺（nHA／PA）复合材料人工肱骨头的体内生物相容性。方法:20只新西兰大白兔行nHA／PA人工肱骨头置换术

术后3、6、12、24周标本行组织学及免疫组织化学检查。结果:仅在nHA／PA植入动物体内3 周时

界膜上少量CD4+

CD8+淋巴细胞浸润。其余各周未见淋巴细胞及炎症细胞侵润。结论:nHA／PA具有良好的体内生物相容性。

Abstract

Objective: To evaluate the compatibility of the nHA/PA composite implant. Methods: The component was implanted into the proximal humeral metaphysis of rabbits. The prosthetic humeral head replacement was performed in 20 rabbits. The rabbits were killed at the 3rd

6th

12th

24th week after operation. Specimens were observed by histology and immunohistochemitry. Results; Immuno-histochemistry results showed that there were some CD4+

CD8+ lymphocytes infiltrated into the interface at the 3rd week

without other inflammatory cells being observed. While at 6th

12th

24th week

neither lymphocytes nor inflammatory cells were seen. Conclusion; The nHA/PA prostheses show good biocompatibility.

关键词

关节置换术羟基磷灰石聚酰胺生物相容性

Keywords

ArthoplastyhydroxyapatitePolyamideBiocompatability

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Related Institution

Department of Orthopedics,College of Clinical Medicine,Chongqing Medical University

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重庆市急救医疗中心眼科

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