Expressions and their Relationship of VEGF and MM P - 2 in Pituitary Adenomas

Tian Jiakun; et al

doi:10.13406/j.cnki.cyxb.2005.06.012

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Expressions and their Relationship of VEGF and MM P - 2 in Pituitary Adenomas

更新时间：2024-01-17

- Expressions and their Relationship of VEGF and MM P - 2 in Pituitary Adenomas
- Journal of Chongqing Medical University Issue 6, Pages: 824-827(2005)
- 作者机构：
  
  1. 重庆医科大学附属第一医院神经外科
  2. 重庆医科大学附属第一医院神经外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.06.012
  CLC： R736.4
- Published：2005，
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[1]田加坤,霍钢,易勇,李九州.VEGF和MMP-2在垂体腺瘤中的表达及其相互关系的研究[J].重庆医科大学学报,2005(06):824-827+845.

Tian Jiakun, et al. Expressions and their Relationship of VEGF and MM P - 2 in Pituitary Adenomas. [J]. Journal of Chongqing Medical University (6):824-827(2005)
[1]田加坤,霍钢,易勇,李九州.VEGF和MMP-2在垂体腺瘤中的表达及其相互关系的研究[J].重庆医科大学学报,2005(06):824-827+845. DOI： 10.13406/j.cnki.cyxb.2005.06.012.

Tian Jiakun, et al. Expressions and their Relationship of VEGF and MM P - 2 in Pituitary Adenomas. [J]. Journal of Chongqing Medical University (6):824-827(2005) DOI： 10.13406/j.cnki.cyxb.2005.06.012.

摘要

目的:探讨血管内皮生长因子（VEGF）和基质金属蛋白酶-2（MMP-2）在垂体腺瘤中的表达及其与垂体腺瘤侵袭性的相关性。方法用免疫组化SP法和RT-PCR方法对55例垂体腺瘤标本的VEGF及MMP-2表达进行研究

分析其表达与侵袭性垂体腺瘤的关系及两者之间的相关性。结果VEGF在侵袭性垂体腺瘤中的强阳性及阳性表达率分别为56．3％和 100％

明显高于非侵袭性垂体腺瘤中的17．4％和56．5％（P<0．05）

MMP-2在侵袭性垂体腺瘤中的强阳性及阳性表达率分别为65．6％和93．8％

明显高于非侵袭性垂体腺瘤中的13．0％和43．5％（P<0．01）。侵袭性垂体腺瘤组中VEGFmRNA的表达明显高于非侵袭性垂体腺瘤组（0．768±0．050

0．209±0．032

P<0．01）

侵袭性垂体腺瘤组中MMP-2 mRNA的表达明显高于非侵袭性垂体腺瘤组（1．126±0．081

0．425±0．083

P<0．01）。侵袭性腺瘤组中MMP-2与VEGF的表达成正相关（r=0．463

P<0．01）

非侵袭性腺瘤组中MMP-2与VEGF的表达无明显相关性。结论MMP-2及VEGF的高表达与垂体腺瘤的侵袭性密切相关。MMP-2与VEGF在肿瘤侵袭及新生血管形成过程中存在着内在联系。

Abstract

Objective; To detect the expressions of VEGF and matrix metalloproteinase -2(MMP-2) in invasive pituitary adenomas and noninvasive pituitary adenomas

and to evaluate the relationship between the expression of VEGF and pituitary adenomas

methods; The expressions of VEGF..MMP-2 and MMP -2 were examined by immunohistochemical method

and the expressions of VEGF and MMP -2 mRNA were also examined by RT - PCR assay. The correlation between VEGF and MMP -2

and the correlation between expression of VEGF

MMP -2 and invasiveness of pituitary adenomas were studied. Results; The intense expression and total expression rate of VEGF of pituitary adenomas patients with invasion (56. 3%

100% respectively) were significantly higher than those without (17.4%

56.5%respectively

P<0.05)

and the intense expression and total expression rate in MMP-2 in pituitary adenomas patients with invasion(65.6%

93. 8% respectively) were also significantly higher than those without (13.0%

43.5% respectively

P < 0.01). Both mRNA expressions of VEGF and MMP - 2 were also observed significantly higher in invasive pituitary adenomas (0.768 ± 0.050

1.126±0.081 respectively) than those without invasion (0.209 ±0.032

0.425 ±0.083 respectively

P<0.01). There was a positive correlation between VEGF and MMP -2 mRNA expressions in invasive pituitary adenomas( r =0. 463

P <0. 01)

and there was no correlation between them in noninvasive pituitary adenomas. Conclusions; VEGF and MMP -2 might be associated with the aggressiveness and invasion in pituitary adenomas

and they might have close relationship in the invasiveness and angiogenesis of pituitary adenomas.

关键词

VEGFMMP-2垂体腺瘤侵袭血管形成

Keywords

VEGFMMP-2Pituitary adenomasinvasionangiogenesis

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