Comparative study on effects of compress lung drain fluid and sustained inflation on beagle dogs with moderately and severe acute respiratory distress syndrome

WANG daoxin

doi:10.13406/j.cnki.cyxb.2005.06.007

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Comparative study on effects of compress lung drain fluid and sustained inflation on beagle dogs with moderately and severe acute respiratory distress syndrome

更新时间：2024-01-17

- Comparative study on effects of compress lung drain fluid and sustained inflation on beagle dogs with moderately and severe acute respiratory distress syndrome
- Journal of Chongqing Medical University Issue 6, Pages: 799-802(2005)
- 作者机构：
  
  1. 重庆医科大学附属第二医院呼吸科
  2. 重庆医科大学生物医学工程系
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.06.007
  CLC： R563.8
- Published：2005，
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[1]王导新,张玲,王智彪,陈文直,杜永洪.压缩肺排肺泡液术与控制性肺膨张术对中、重度ARDS模型beagle犬的实验研究[J].重庆医科大学学报,2005(06):799-802.

WANG daoxin. Comparative study on effects of compress lung drain fluid and sustained inflation on beagle dogs with moderately and severe acute respiratory distress syndrome. [J]. Journal of Chongqing Medical University (6):799-802(2005)
[1]王导新,张玲,王智彪,陈文直,杜永洪.压缩肺排肺泡液术与控制性肺膨张术对中、重度ARDS模型beagle犬的实验研究[J].重庆医科大学学报,2005(06):799-802. DOI： 10.13406/j.cnki.cyxb.2005.06.007.

WANG daoxin. Comparative study on effects of compress lung drain fluid and sustained inflation on beagle dogs with moderately and severe acute respiratory distress syndrome. [J]. Journal of Chongqing Medical University (6):799-802(2005) DOI： 10.13406/j.cnki.cyxb.2005.06.007.

摘要

目的:探讨对中、重度急性呼吸窘迫综合征模型犬实施压缩肺排肺泡液术（CLDF）及控制性肺膨张（SI）技术后

机体氧合及呼吸力学的改善情况。方法:12只纯种beagle犬随机分为两组

用油酸建立出中、重度急性呼吸窘迫综合征模型犬

组实施控制性肺膨张

采用35 cmH2O-40 cmH2O压力

持续20s

另一组实施压缩肺排肺泡液术

采用15cmH2O-20 cmH2O 压力

持续15s

两组在实施此技术后继续行机械通气。在实施前、中、后动态观察动脉血气、肺力学、血液动力学变化情况。结果:SI组血气的改善并不明显（P<0．05）

压缩肺排肺泡液术组动脉血气的改变明显（P>0．05）

对肺力学的影响

CLDF组肺力学明显降低（P<0．05）

SI组下降不明显（P>0．05）。血流动力学的改变均不明显。结论:在中、重度急性呼吸窘迫综合征实施压缩肺排肺泡液术能成功排出肺泡水肿液

对动脉血气、肺力学的有明显改善

而控制性肺膨张技术的效果不明显。但两种措施在beagle犬ARDS模型上实施都是安全的。

Abstract

Objective: To study the effects of compress lung drain fluid(CLDF) and sustained inflation( SI) on beagle dogs with moderately and severe acute respiratory distress syndrome. Methods: twelve beagle dogs were randomly assigned to two groups. SI was applied at pressure of 35 cmH2O -40 cmH2O for 20s in one group

compress lung drain fluid (CLDF) was applied at pressure of 15cmH2O- 20 cmH2O for 15 s in anther group

then was continued ventilation

and blood gas

and lung mechanics were observed. Results; Pressure of arterial oxygen and arterial saturation were improved in CLDF group( P <0.05)

and pressure of arterial oxygen and arterial saturation were not improved significantly in SI group( P >0. 05 ). PIP

Pp were decreased in CLDF group( P < 0. 05 )

while those were not improved in SI group

Both two methods were safety. Conclusion: Compress lung drain fluid (CLDF) can improve oxygenation and lung mechanics in beagle dogs with moderately and severe acute respiratory distress syndrome

have no evident effects while SI. However two methods are safe.

关键词

ARDS压缩肺排肺泡液术控制性肺膨张血气

Keywords

acute respiratory distress syndromecompress lung drain fluidsustained inflationblood gas assay

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Department of Central ICU,the First Affiliated Hospital,Chongqing Medical University

重庆医科大学附属第一医院中心ICU

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