The study of anticoagulation in elderly patients with nonvalvular atrial fibrillation

LI Lihua; et al

doi:10.13406/j.cnki.cyxb.2005.04.039

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The study of anticoagulation in elderly patients with nonvalvular atrial fibrillation

更新时间：2024-01-17

- The study of anticoagulation in elderly patients with nonvalvular atrial fibrillation
- Journal of Chongqing Medical University Issue 4, Pages: 618-620(2005)
- 作者机构：
  
  1. 重庆医科大学附属第一医院心内科
  2. 重庆医科大学附属第一医院心内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.04.039
  CLC： R541.7
- Published：2005，
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[1]李骊华,陈运贞,邓国兰.华法林在老年非瓣膜性房颤的抗凝研究[J].重庆医科大学学报,2005(04):618-620.

LI Lihua, et al. The study of anticoagulation in elderly patients with nonvalvular atrial fibrillation. [J]. Journal of Chongqing Medical University (4):618-620(2005)
[1]李骊华,陈运贞,邓国兰.华法林在老年非瓣膜性房颤的抗凝研究[J].重庆医科大学学报,2005(04):618-620. DOI： 10.13406/j.cnki.cyxb.2005.04.039.

LI Lihua, et al. The study of anticoagulation in elderly patients with nonvalvular atrial fibrillation. [J]. Journal of Chongqing Medical University (4):618-620(2005) DOI： 10.13406/j.cnki.cyxb.2005.04.039.

摘要

目的:研究适宜剂量的华法林对老年非瓣膜性房颤的中国人群血栓栓塞事件的影响及确定合适的INR值范围。方法:37例老年非瓣膜性房颤患者

采用华法林进行抗凝治疗

随访和定期监测INR值。结果:华法林每日剂量在2.11mg

.41mg时

INR值在2.0

.5;华法林剂量在2.41mg

.70mg时

INR值在2.5

.0。所有患者均未出现与房颤相关性血栓栓塞及严重出血事件。增减不同剂量的华法林达到目标INR值所需天数不同。结论:采用华法林抗凝治疗

可有效预防老年非瓣膜性房颤脑卒中的发生

华法林剂量为2.11

.41mg

INR值范围在2.0

.5时

安全性较好。

Abstract

Objective:To study the optimal intensity of warfarin therapy for prevention of thromboembolism in elderly patients with nonvalvular atrial fibrillation and to determine the safe range of INR.Methods:Warfarin was used for anticoagulant therapy for thirty-seven patients with nonvalvular atrial fibrillation.The patients were followed up and INRs were measured regularly.Results:When the dosage of warfarin changed from 2.11 milligram to 2.41 milligram

the range of INR was between two and two point five (2.0～2.5).When the dosage changed from 2.41 milligram to 2.70 milligram

the INR was between two point five and three (2.5～3.0).No atrial fibrillation related thromboembolism and major hemorrhage occurred in all patients.It required different number of days to reach the safe INR limits by raising or lowering the dosage of warfarin in the patients.Conclusion:Warfarin is effective in preventing stroke in elderly patients with nonvalvular atrial fibrillation.The optimal intensity of warfarin ranges from 2.11 milligram to 2.41 milligram and the safe range of INR is between two and two point five (2.0～2.5).

关键词

华法林心房颤动血栓栓塞抗凝治疗

Keywords

warfarinatrial fibrillationthromboembolismAnticoagulation

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Related Institution

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