Establishment of Botnia clamp technique in healthy women

CHENG Qingfeng; et al

doi:10.13406/j.cnki.cyxb.2005.04.032

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Establishment of Botnia clamp technique in healthy women

更新时间：2024-01-17

- Establishment of Botnia clamp technique in healthy women
- Journal of Chongqing Medical University Issue 4, Pages: 598-600(2005)
- 作者机构：
  
  1. 重庆医科大学附属第一医院内分泌科
  2. 重庆医科大学附属第一医院内分泌科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.04.032
  CLC： R587.1
- Published：2005，
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[1]程庆丰,李启富,白晓苏,冯静,黄健康,刘秀容.正常女性Botnia钳夹术的建立[J].重庆医科大学学报,2005(04):598-600.

CHENG Qingfeng, et al. Establishment of Botnia clamp technique in healthy women. [J]. Journal of Chongqing Medical University (4):598-600(2005)
[1]程庆丰,李启富,白晓苏,冯静,黄健康,刘秀容.正常女性Botnia钳夹术的建立[J].重庆医科大学学报,2005(04):598-600. DOI： 10.13406/j.cnki.cyxb.2005.04.032.

CHENG Qingfeng, et al. Establishment of Botnia clamp technique in healthy women. [J]. Journal of Chongqing Medical University (4):598-600(2005) DOI： 10.13406/j.cnki.cyxb.2005.04.032.

摘要

目的:建立一种能同时独立评价胰岛B细胞功能和胰岛素敏感性的方法。方法:联合静脉葡萄糖耐量试验（IVGTT）与高胰岛素-正常葡萄糖钳夹术（简称正糖钳夹术）—即Botnia钳夹术

评估13例健康女性志愿者的胰岛B细胞功能与胰岛素敏感性

并与常规正糖钳夹术进行比较。结果:Botnia钳夹术与常规正糖钳夹术稳态期（150

80 min）葡萄糖代谢率分别为（13.11±1.71）mg/（kg.min）和（13.34±1.41）mg/（kg.min）

0.05;稳态期血糖浓度分别为（5.14±0.12）mmol/L和（5.15±0.14）mmol/L

0.05。结论:IVGTT并不影响随后正糖钳夹术中稳态葡萄糖代谢率。Botnia钳夹术可同时评价胰岛B细胞功能和胰岛素敏感性

是一种值得推广的方法。

Abstract

Objective:To establish a method for independent assessment of insulin secretion and insulin sensitivity (SI) simultaneously.Methods:B-cell function and insulin sensitivity in 13 healthy feminine subjects were assessed by applying intravenous glucose tolerance test combined with hyperinsulinemic-euglycemic-clamp and the test was compared with regular hyperinsulinemic- euglycemic-clamp.Results:There was no signal statistical difference when campared the stable (150～180 min)M-value obtained during the Botnia clamp with the stable M-value from a regular hyperinsulinemic- euglycemic-clamp (13.11±1.71mg/(kg·min)

13.34±1.41mg/(kg·min)

respectively

P>0.05).Stable glucose concentrations were (5.14±0.12)mmol/L and(5.15±0.14)mmol/L

respectively

P>0.05.Conclusion:The prior glucose bolus does not affect the following euglycemic clamp.The Botnia clamp is a useful method for simultaneous independent assessment of insulin secretion and insulin sensitivity.

关键词

静脉葡萄糖耐量试验高胰岛素-正葡萄糖钳夹术胰岛B细胞功能胰岛素敏感性

Keywords

Intravenous glucose tolerance testHyperinsulinemic-euglycemic-clampB-cell functioninsulin sensitivity

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