The relationship between liver pathologic histology and levels of serum HBV-DNA,ALT in patients with chronic hepatitis B

JIANG Yongfang; et al

doi:10.13406/j.cnki.cyxb.2005.04.026

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The relationship between liver pathologic histology and levels of serum HBV-DNA,ALT in patients with chronic hepatitis B

更新时间：2024-01-17

- The relationship between liver pathologic histology and levels of serum HBV-DNA,ALT in patients with chronic hepatitis B
- Journal of Chongqing Medical University Issue 4, Pages: 578-580(2005)
- 作者机构：
  
  1. 中南大学湘雅二医院肝病研究中心
  2. 湖南省衡山县人民医院内科,长沙,410011
  3. ,湖南,421400
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.04.026
  CLC： R512.62
- Published：2005，
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[1]蒋永芳,旷晖峰.慢性乙型病毒性肝炎患者血清HBV DNA水平和谷丙转氨酶与肝组织病理的关系[J].重庆医科大学学报,2005(04):578-580.

JIANG Yongfang, et al. The relationship between liver pathologic histology and levels of serum HBV-DNA,ALT in patients with chronic hepatitis B. [J]. Journal of Chongqing Medical University (4):578-580(2005)
[1]蒋永芳,旷晖峰.慢性乙型病毒性肝炎患者血清HBV DNA水平和谷丙转氨酶与肝组织病理的关系[J].重庆医科大学学报,2005(04):578-580. DOI： 10.13406/j.cnki.cyxb.2005.04.026.

JIANG Yongfang, et al. The relationship between liver pathologic histology and levels of serum HBV-DNA,ALT in patients with chronic hepatitis B. [J]. Journal of Chongqing Medical University (4):578-580(2005) DOI： 10.13406/j.cnki.cyxb.2005.04.026.

摘要

目的:探讨慢性乙肝患者HBV DNA水平、血清谷丙转氨酶和肝组织病理分级分期的关系。方法:应用荧光定量聚合酶链反应法（PCR）对285例慢性乙型肝炎患者血清进行HBV DNA定量检测和常规肝功能生化检查

并与同期肝组织活检病理结果对比分析。结果:血清HBV DNA水平与肝组织炎症及纤维化无明显相关性（γG=0.357

P>0.05;γS=0.507

P>0.05）。在230例HBeAg阳性的患者中

血清HBV DNA水平与肝组织炎症呈明显的负相关（γ=-0.659

P<0.001）。随着肝脏炎症活动度增加

ALT值升高也愈明显

差别有显著意义。结论:血清HBV DNA定量与肝组织炎症及纤维化无明显关系。在HBeAg阳性的患者中

血清HBV DNA水平与肝组织炎症呈负相关。ALT与肝脏炎症活动度有明显相关性

提示ALT仍是观察炎症变化的敏感指标。

Abstract

Objective:To investigate the relationship between serum HBV DNA levels

aminotransferase and grading and staging of liver tissues in patients with chronic hepatitis B.Methods:Routine biochemical liver function tests and serum HBV DNA level was assayed by amplisensor quantitative polymerase chain reaction in 285 patients;and the liver biopsy was performed and the grading and staging of the liver were routinely obtained.Results:There was not obvious correlation between serum HBV DNA level and the grading and staging.A significant inverse relationship between the HBV DNA and hepatitis activity was demonstrated in 230 patients with positive HBeAg.The serum ALT level was consistent with hepatitis activity.Conclusion:There is no significant correlation between serum HBV DNA and grading and staging.In HBeAg-positive patients

serum HBV DNA levels showed a significant negative correlation with hepatic activity index.The higher ALT in serum shows the more severe hepatitis activity

and ALT could be helpful for assessing the hepatitis activity.

关键词

慢性肝炎HBVDNA谷丙转氨酶肝组织

Keywords

Chronic hepatitisHBV DNAAminotransferaseLiver tissues

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