Objective:To obtain experiences of anesthesia and its perioperative management for clinical liver translantation.Methods:40 healthy pigs were divided into two groups at random:20 donators

20 receivers.The oral intubation and total intravenous anesthesia(TIVA) were adopted in all pigs.The hemodynamic changes were continuously monitored during the operating phases.The changes of blood biochemistry and arterial blood gas were monitored during preanhepatic phase

anhepatic phase and primary neohepatic phase in 20 receivers.Results:Because of the special anatomy of pigs

the intubation was difficult and requires higher techniques.The oral intubation was successful in 39 cases

and tracheotomy in 1 case.There were remarkable hemodynamic changes and severe metabolic acidosis during anhepatic phase and primary neohepatic phase being compared with the preanhepatic phase

and temporary serum kalium concentration increases during primary neohepatic phase.Conclusion:The oral intubation can be adopted in pigs.Anesthesia can be shallow during the anhepatic phase.Hemodynamics and acid base and electrolyte equilibrium change significantly.Therefore it is very important to monitor hemodynamics and blood biochemistry and arterial blood gas in order to prevent and manage their disturbance during orthotopic liver transplantation.