An experimental study on the effect of somatostatin in antagonizing the maladjustment of sexual hormones homeostasis induced by tamoxifen

ZENG Xizhi; et al

doi:10.13406/j.cnki.cyxb.2005.04.013

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An experimental study on the effect of somatostatin in antagonizing the maladjustment of sexual hormones homeostasis induced by tamoxifen

更新时间：2024-01-17

- An experimental study on the effect of somatostatin in antagonizing the maladjustment of sexual hormones homeostasis induced by tamoxifen
- Journal of Chongqing Medical University Issue 4, Pages: 530-532(2005)
- 作者机构：
  
  1. 重庆医科大学附属第一医院内分泌外科
  2. 重庆医科大学附属第一医院内分泌外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.04.013
  CLC： R737.9
- Published：2005，
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[1]曾希志,姚榛祥.生长抑素逆转三苯氧胺对性激素内环境影响的实验研究[J].重庆医科大学学报,2005(04):530-532.

ZENG Xizhi, et al. An experimental study on the effect of somatostatin in antagonizing the maladjustment of sexual hormones homeostasis induced by tamoxifen. [J]. Journal of Chongqing Medical University (4):530-532(2005)
[1]曾希志,姚榛祥.生长抑素逆转三苯氧胺对性激素内环境影响的实验研究[J].重庆医科大学学报,2005(04):530-532. DOI： 10.13406/j.cnki.cyxb.2005.04.013.

ZENG Xizhi, et al. An experimental study on the effect of somatostatin in antagonizing the maladjustment of sexual hormones homeostasis induced by tamoxifen. [J]. Journal of Chongqing Medical University (4):530-532(2005) DOI： 10.13406/j.cnki.cyxb.2005.04.013.

摘要

目的:探讨八肽生长抑素奥曲肽（OCT）对三苯氧胺（TAM）所致实验性大鼠性激素内环境失衡的逆转作用。方法:Wistar雌鼠接受致癌剂二甲基苯蒽8周后随机分为对照组和治疗组

治疗组采用OCT

TAM或二者联合治疗14周。应用酶免疫分析法测定血清中雌二醇（E2）、孕酮（P）、泌乳素（PRL）、卵泡刺激素（FSH）和黄体生成素（LH）的水平。结果:血清E2和P含量在TAM组均明显高于对照组（P<0.05）

而OCT+TAM组与对照组无明显差异（P>0.05）;PRL含量在OCT组、TAM组和OCT+TAM组（1.40ng/ml）均显著低于对照组（2.85ng/ml）（P<0.05

P<0.01）。结论:OCT在体内可以拮抗TAM对内源性雌激素的影响

从而减少因性激素内环境不平衡所致的副作用。

Abstract

Objective:To investigate the effect of somatostatin (SST) analog octreotide (OCT) in antagonizing the maladjustment of sexual hormones homeostasis induced by tamoxifen(TAM) in rat.Methods:Eight weeks after DMBA(a single dose 100mg/kg body weight by subcutaneous injection) application

the female Wistar rats were randomized to control and treatment groups.Rats in treatment groups underwent TAM(1mg/kg 5 times weekly for 14 weeks by subcutaneous injection)

OCT(0.1mg/kg bid for 14 weeks by subcutaneous injection)

or the combination of both.The levels of sexual hormones (estradiol

progesterone

prolactin

follicle stimulating hormone

luteinizing hormone) were assessed by enzyme immunoassay(EIA).Results:The levels of estradiol and progesterone in serum were remarkably higher in TAM group(21.69pg/ml

6.14ng/ml) than in control group(16.92pg/ml

4.13ng/ml) respectively(P<0.05

P<0.01)

and there was no significant difference between OCT+TAM group(14.58pg/ml

3.88ng/ml) and control group.The prolactin concentrations in serum in the three treatment groups were lower than in control group(P<0.05

P<0.01).Conclusion:OCT can antagonize the effect of TAM to ascend the level of endogenous estrogen

and abolish the ill-effects resulting from maladjustment of sexual hormones homeostasis.

关键词

奥曲肽三苯氧胺实验性乳腺癌

Keywords

octreotideTamoxifenExperimental mammary carcinoma

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