A role of sodium selenite in regulating expression of Cyclooxygenase-2(COX-2) mRNA in rat mesangial cells

WEI Qianping; et al

doi:10.13406/j.cnki.cyxb.2005.04.003

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A role of sodium selenite in regulating expression of Cyclooxygenase-2(COX-2) mRNA in rat mesangial cells

更新时间：2024-01-17

- A role of sodium selenite in regulating expression of Cyclooxygenase-2(COX-2) mRNA in rat mesangial cells
- Journal of Chongqing Medical University Issue 4, Pages: 493-496(2005)
- 作者机构：
  
  1. 重庆医科大学附属第一医院内分泌科
  2. 重庆医科大学超声工程研究所
  3. Department of Molecular Medicine
  4. Karolinska Institute Stockholm,17176
  5. Sweden,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.04.003
  CLC： R587.2
- Published：2005，
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[1]魏倩萍,邓华聪,赵劼,Harvest F.Gu.亚硒酸钠对大鼠肾小球系膜细胞表达COX-2 mRNA的调控[J].重庆医科大学学报,2005(04):493-496.

WEI Qianping, et al. A role of sodium selenite in regulating expression of Cyclooxygenase-2(COX-2) mRNA in rat mesangial cells. [J]. Journal of Chongqing Medical University (4):493-496(2005)
[1]魏倩萍,邓华聪,赵劼,Harvest F.Gu.亚硒酸钠对大鼠肾小球系膜细胞表达COX-2 mRNA的调控[J].重庆医科大学学报,2005(04):493-496. DOI： 10.13406/j.cnki.cyxb.2005.04.003.

WEI Qianping, et al. A role of sodium selenite in regulating expression of Cyclooxygenase-2(COX-2) mRNA in rat mesangial cells. [J]. Journal of Chongqing Medical University (4):493-496(2005) DOI： 10.13406/j.cnki.cyxb.2005.04.003.

摘要

目的:观察亚硒酸钠对大鼠肾小球系膜细胞（RGMC）表达环氧化酶-2（COX-2）的影响

从而研究硒在抗糖尿病肾病中的作用机制。方法:分别以高葡萄糖、糖基化终产物

高胰岛素和过氧化氢孵育RGMC;先给予亚硒酸钠预处理细胞后

再分别给予上述4种因素孵育RGMC

观察细胞COX-2 mRNA的表达。结果:4种刺激因素均可作为独立因素

导致RGMC COX-2 mRNA表达量的增加;亚硒酸钠能抑制上述4种因素所致的COX-2 mRNA的表达。结论:亚硒酸钠通过抑制COX-2 mRNA在RGMC中的表达

从而有效地防治糖尿病肾病的发生发展。

Abstract

Objective:To observe the effect of sodium selenite on expression of Cyclooxygenase-2 （COX-2） mRNA in rat mesangial cells （RGMC）

and to study the mechanism of sodium selenite in anti-diabetic nephropathy.Methods:RGMC was incubated with high glucose

advanced glycosylation end products （AGE）

high insulin and H

respectively;simultaneously

RGMC pre-treated with sodium selenite was incubated with above factors.The expression of COX-2 mRNA was detected and compared.Results:The four factors increased the expression of COX-2 mRNA independently;sodium selenite inhibited the expression of COX-2 mRNA by the four factors distinctly.Conclusion:Sodium selenite suppresses the expression of COX-2 mRNA in RGMC

which suggests that sodium selenite may play a significant role in the prevention of diabetic nephropathy by inhibition of the expression of COX-2 mRNA in RGMC.

关键词

亚硒酸钠环氧化酶-2糖尿病肾病大鼠肾小球系膜细胞

Keywords

Sodium seleniteCyclooxygenase-2diabetic nephropathyRat mesangial cells

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Department of Endocrinology,College of Clinical Medicine,Chongqing Medical University

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