Clinical analysis of anticentromere antibodies positive in 26 cases

CHEN Pu; et al

doi:10.13406/j.cnki.cyxb.2005.03.044

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Clinical analysis of anticentromere antibodies positive in 26 cases

更新时间：2024-01-17

- Clinical analysis of anticentromere antibodies positive in 26 cases
- Journal of Chongqing Medical University Issue 3, Pages: 461-462(2005)
- 作者机构：
  
  1. 重庆医科大学临床学院检验科
  2. 重庆医科大学临床学院检验科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.03.044
  CLC： R446.6
- Published：2005，
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[1]陈瀑,严立,祝继华.26例抗着丝点抗体阳性分析[J].重庆医科大学学报,2005(03):461-462+484.

CHEN Pu, et al. Clinical analysis of anticentromere antibodies positive in 26 cases. [J]. Journal of Chongqing Medical University (3):461-462(2005)
[1]陈瀑,严立,祝继华.26例抗着丝点抗体阳性分析[J].重庆医科大学学报,2005(03):461-462+484. DOI： 10.13406/j.cnki.cyxb.2005.03.044.

CHEN Pu, et al. Clinical analysis of anticentromere antibodies positive in 26 cases. [J]. Journal of Chongqing Medical University (3):461-462(2005) DOI： 10.13406/j.cnki.cyxb.2005.03.044.

摘要

目的:提高临床对抗着丝点抗体的认识。方法:回顾分析了26例抗着丝点抗体阳性患者临床资料。结果:26例抗着丝点抗体阳性患者中系统性硬化症10例（38.4%）

系统性红斑狼疮4例（15.4%）

干燥综合症和类风湿关节炎分别3例（11.5%）

混合结缔组织病、仅有雷诺现象各2例（7.7%）

CREST综合征和不明原因肝脏疾病各1例（3.8%）。着丝点抗体可同时出现其它自身抗体。结论:抗着丝点抗体可出现在多种疾病中

着丝点抗体并非CREST综合征的特异性抗体

抗着丝点抗体阳性患者最多见临床症状为雷诺现象（53.8%）

其次为皮肤硬化（34.6%）。

Abstract

Objective:To comprehend the clinical significance of anticentromere antibodies(ACA)positive in patients.Methods:A total of 26 patients with positive ACA were studied retrospectively.Results:There were 10 patients with systemic sclerosis(38.4%)

4 patients with systemic lupus erythematosus(15.4%)

3 patients with Sjogren’s syndrome and rheumatoid arthritis(11.5%)respectively

2 patients with mixed connective tissue disease and Raynaud phenomenon(7.7%)respectively

1 patient with CREST syndrome and 1 patient with liver disease of unknown causes (3.8%).ACA and other autoantibodies were present in serum at the same time.Conclusion:ACA is found in many diseases.ACA is not specific for CREST syndrome.The major clinical characteristics of the patients correlated with ACA are Raynaud phenomenon(53.8%)and scleroderma(34.6%).

关键词

抗着丝点抗体系统性硬化症雷诺现象

Keywords

Anticertromere antibodiessystemic sclerosisRaynaud phenomenon

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Yang Jinliang

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