Study on the efficacy and safety of N-acetyl-L-cysteine injection in mucolytic treatment of respiratory tract infection administered by inhalation route

GUO Shuliang; et al

doi:10.13406/j.cnki.cyxb.2005.03.038

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Study on the efficacy and safety of N-acetyl-L-cysteine injection in mucolytic treatment of respiratory tract infection administered by inhalation route

更新时间：2024-01-17

- Study on the efficacy and safety of N-acetyl-L-cysteine injection in mucolytic treatment of respiratory tract infection administered by inhalation route
- Journal of Chongqing Medical University Issue 3, Pages: 444-446(2005)
- 作者机构：
  
  1. 重庆医科大学临床学院呼吸内科
  2. 重庆医科大学临床学院呼吸内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.03.038
  CLC： R56
- Published：2005，
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[1]郭述良,吴亚梅,徐玲,陈涛,唐小葵,罗永艾.N-乙酰半胱氨酸注射剂雾化吸入在急慢性呼吸道感染溶痰治疗中的疗效与安全性评价[J].重庆医科大学学报,2005(03):444-446.

GUO Shuliang, et al. Study on the efficacy and safety of N-acetyl-L-cysteine injection in mucolytic treatment of respiratory tract infection administered by inhalation route. [J]. Journal of Chongqing Medical University (3):444-446(2005)
[1]郭述良,吴亚梅,徐玲,陈涛,唐小葵,罗永艾.N-乙酰半胱氨酸注射剂雾化吸入在急慢性呼吸道感染溶痰治疗中的疗效与安全性评价[J].重庆医科大学学报,2005(03):444-446. DOI： 10.13406/j.cnki.cyxb.2005.03.038.

GUO Shuliang, et al. Study on the efficacy and safety of N-acetyl-L-cysteine injection in mucolytic treatment of respiratory tract infection administered by inhalation route. [J]. Journal of Chongqing Medical University (3):444-446(2005) DOI： 10.13406/j.cnki.cyxb.2005.03.038.

摘要

目的:验证N-乙酰半胱氨酸（NAC）注射剂雾化吸入对痰液黏稠和排痰困难患者祛痰的临床疗效和安全性。方法:征集40例痰量多、黏稠及排痰困难的急慢性呼吸道感染患者

随机分入NAC试验组（18例）和盐酸溴已新对照组（22例）

分别给予NAC注射液300mg/3ml加生理盐水5ml雾化吸入

每日2次和盐酸溴已新注射液6mg/3ml加生理盐水5ml雾化吸入

每日2次进行治疗和比较

疗程6天。结果:两组病人用药后

咳嗽、痰量、痰性状评分均逐渐下降

但两组之间每天评分比较均无显著性差异（P>0.05）。试验组有效率66.67%（PP集）

对照组有效率61.11%（PP集）

两组疗效差异无统计学意义（P>0.05）。不良反应发生率试验组为6.25%

对照组4.55%

差异亦无统计学意义（P>0.05）。结论:临床试验结果显示

NAC注射剂雾化吸入具有改善患者咳嗽咳痰和排痰困难临床症状的作用

安全性和耐受性良好。

Abstract

Objective:To evaluate the clinical efficacy and safety of N-acetyl-L-cysteine (NAC)injection in mucolytic treatment of patients with thick

viscous sputum.Methods:40 patients entered the parallel

randomized clinical trial

18 in study group were treated with NAC injection of 300mg/3ml and 22 in control group with bromhexine injection of 6mg/3ml

b.i.d

for 6 days.Both were given by inhalation route.Results:After treatment reduction in sputum quantity

viscosity and cough severity were shown in both of the two groups.The effective rate of NAC group was 66.67%and that of bromhexine was 61.11%.The adverse events rates of the two groups were 6.25% and 4.55%

respectively.There were no significant differences between these two groups in effective rates

daily mark(scores) of clinical parameters and adverse effect rates (P>0.05).Conclusion:NAC injection is an effective and well-tolerated mucolytic agent as administered by inhalation route for patients with thick

viscid sputum.

关键词

N-乙酰半胱氨酸溶痰药物吸入疗法临床试验

Keywords

N-Acetyl-L-CysteineMucolytic agentsInhalation therapyclinical trial

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