Expression and significance of Clusterin ,bcl-2 and FasL in prostate cancer

CHEN Gang; et al

doi:10.13406/j.cnki.cyxb.2005.03.028

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Expression and significance of Clusterin ,bcl-2 and FasL in prostate cancer

更新时间：2024-01-17

- Expression and significance of Clusterin ,bcl-2 and FasL in prostate cancer
- Journal of Chongqing Medical University Issue 3, Pages: 409-411(2005)
- 作者机构：
  
  1. 重庆医科大学临床学院泌尿外科
  2. 重庆医科大学临床学院泌尿外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.03.028
  CLC： R737.25
- Published：2005，
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[1]陈刚,唐伟.Clusterin、bcl-2及FasL在前列腺癌中的表达及相关性研究[J].重庆医科大学学报,2005(03):409-411+420.

CHEN Gang, et al. Expression and significance of Clusterin ,bcl-2 and FasL in prostate cancer. [J]. Journal of Chongqing Medical University (3):409-411(2005)
[1]陈刚,唐伟.Clusterin、bcl-2及FasL在前列腺癌中的表达及相关性研究[J].重庆医科大学学报,2005(03):409-411+420. DOI： 10.13406/j.cnki.cyxb.2005.03.028.

CHEN Gang, et al. Expression and significance of Clusterin ,bcl-2 and FasL in prostate cancer. [J]. Journal of Chongqing Medical University (3):409-411(2005) DOI： 10.13406/j.cnki.cyxb.2005.03.028.

摘要

目的:通过检测新的凋亡抑制因子Clusterin在前列腺癌组织中的表达

探讨其与前列腺癌发生发展的关系及其与bcl-2和FasL表达的关系。方法:A采用免疫组织化学染色法检测Clusterin、bcl-2、FasL在10例正常前列腺组织、15例良性前列腺增生组织（BPH）、49例前列腺癌组织标本中的表达。结果:Clusterin在前列腺正常、增生、癌组织中的阳性及弱阳性表达率分别为10%（1/10）、66.6%（10/15）、91.8%（45/49）。前列腺癌组织中Clusterin表达水平明显高于前列腺正常组织（P<0.005）及增生组织（P<0.005）

且在癌组织中与肿瘤临床分期（P<0.001）、病理分级（P<0.001）呈正相关。比较Clusterin与bcl-2在前列腺癌组织中的表达

差异有显著性（P<0.05）。比较Clusterin与FasL在前列腺癌组织中的表达

差异也有显著性（P<0.05）。结论:Clusterin基因可能通过抑制凋亡在前列腺癌的发生发展中发挥重要作用

且其表达与bcl-2、FasL的异常表达密切相关。

Abstract

Objective:To investigate the expression and significance of an inhibitor gene of apoptosis

Clusterin

in prostate cancer

and its relationship with the expression of bcl-2

FasL.Methods:The expression of Clusterin

bcl-2 and FasL in sample of 10 normal prostate

15 BPH and 49 prostate cancer were examined by immunohistochemical stain.Results:The rate of positive or weak positive for normal prostate

BPH and prostate cancer was 10%(1/10)

66.6%(10/15)and 91.8%(45/49) respectively.The expression level of Clusterin in prostate cancer was much higher than in normal prostate(P<0.005)

BPH(P<0.005)

and it was related positively with clinical stage(P<0.001)and pathological grade(P<0.001)of prostate cancer.Clusterin positive cases were strongly associated with bcl-2 expression(P<0.05)and FasL expression(P<0.05).Conclusion:Clusterin

alone or in cooperarion with bcl-2 and FasL

may play an important role in the onset and progression of prostate cancer by the antiapoptosis pathway.

关键词

前列腺肿瘤凋亡clusterinFasLBcl-2免疫组织化学

Keywords

Prostatic neoplasmsapoptosisclusterinFasLBcl-2immunohistochemistry

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