Thymosin β<sub>4</sub> raises survival rate and down-regulatesinflammatory mediators in septic shock mice

ZHAO Yuguang; et al

doi:10.13406/j.cnki.cyxb.2005.03.019

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Thymosin β₄ raises survival rate and down-regulatesinflammatory mediators in septic shock mice

更新时间：2024-01-17

- Thymosin β₄ raises survival rate and down-regulatesinflammatory mediators in septic shock mice
- Journal of Chongqing Medical University Issue 3, Pages: 376-378(2005)
- 作者机构：
  
  1. 重庆医科大学临床学院普外科
  2. 重庆医科大学临床学院神经内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.03.019
  CLC： R96
- Published：2005，
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[1]赵裕光,时德,王爽.胸腺肽β4提高内毒素休克小鼠存活率并下调炎症介质释放[J].重庆医科大学学报,2005(03):376-378.

ZHAO Yuguang, et al. Thymosin β₄ raises survival rate and down-regulatesinflammatory mediators in septic shock mice. [J]. Journal of Chongqing Medical University (3):376-378(2005)
[1]赵裕光,时德,王爽.胸腺肽β4提高内毒素休克小鼠存活率并下调炎症介质释放[J].重庆医科大学学报,2005(03):376-378. DOI： 10.13406/j.cnki.cyxb.2005.03.019.

ZHAO Yuguang, et al. Thymosin β₄ raises survival rate and down-regulatesinflammatory mediators in septic shock mice. [J]. Journal of Chongqing Medical University (3):376-378(2005) DOI： 10.13406/j.cnki.cyxb.2005.03.019.

摘要

目的:研究胸腺肽β4（thymosinβ4

Tβ4）对内毒素休克小鼠72h存活率的影响

检测TNF-α及IL-1α变化

初步探讨Tβ4治疗内毒素休克的机制。方法:选用清洁级昆明小鼠腹腔注射脂多糖（LPS）制备内毒素休克动物模型

①观察内毒素休克前后Tβ4变化情况。②Tβ4对内毒素休克小鼠存活率的影响。动物随机分为4组

每组30只

均腹腔注射LPS（25mg/kg）

Ⅰ组为LPS对照组

Ⅱ、Ⅲ、Ⅳ组分别于LPS腹腔注射后0h;0h、2h;0h、2h、4h尾静脉注射Tβ4（5mg/kg）

观察72h存活率。③ELISA法检测Tβ4对内毒素休克小鼠血浆TNF-α及IL-1α变化情况。结果:Tβ4在内毒素休克小鼠的血浆中明显降低

Tβ4可提高内毒素休克小鼠72h存活率

并下调TNF-α及IL-1α的释放。结论:Tβ4治疗内毒素休克应在LPS腹腔注射后0h、2h、4h连续注射Tβ4（5mg/kg）

实验提示Tβ4可能是通过下调炎症介质的释放来治疗内毒素休克的。

Abstract

Objective:To explore the mechanism of action of thymosin β 4 (Tβ 4) in septic shock by observing the 72h survival rate of septic shock mice treated with thymosin β 4 and exploring the changes of TNF-α and IL-1α.Methods:LPS(lipopolysaccharide) was intraperitoneally injected into clean Kunming mice to establish the animal model.①The Tβ 4

between normal and septic shock mice were determined.②The survival rate of septic shock mice was studied by intraperitoneal injection of Tβ 4.Animals were divided into four groups of 30 and each received LPS(25mg/kg)intraperitoneal injection.Group Ⅰ was LPS control group.GroupⅡ

Ⅲ and Ⅳ were individually injected with Tβ 4 at 0h

2h;0h

4h post LPS through caudal vein.③TNF-α and IL-1α were examined in septic shock mice by ELISA.Results:Tβ 4 was obviously decreased in the blood of septic shock mice.Tβ 4 could raise the 72h survival rate of septic shock mice and down-regulate inflammatory mediators.Conclusion:The optimal protective methods in the mouse appears to be 5mg/kg Tβ 4 given immediately following(0h) and at 2h and 4h successively post LPS.Tβ 4 down-regulates the inflammatory mediators

which may be the mechanism of Tβ 4 in curing the septic shock.

关键词

胸腺肽β4存活率TNF-αIL-1α

Keywords

Thymosin β4survival rateTumor necrosis factor-α (TNF-α)Interleukin-1 α(IL-1α)

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Thymosin β4 raises survival rate and down-regulatesinflammatory mediators in septic shock mice

DOI：10.13406/j.cnki.cyxb.2005.03.019

摘要

Abstract

关键词

Keywords

references

Thymosin β₄ raises survival rate and down-regulatesinflammatory mediators in septic shock mice