Autologous peripheral blood stem cell transplantation with tandem transfusion of stem cells in treating hematological malignant disease-A report of 4 cases

LOU Shifeng; et al

doi:10.13406/j.cnki.cyxb.2005.02.040

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Autologous peripheral blood stem cell transplantation with tandem transfusion of stem cells in treating hematological malignant disease-A report of 4 cases

更新时间：2024-01-17

- Autologous peripheral blood stem cell transplantation with tandem transfusion of stem cells in treating hematological malignant disease-A report of 4 cases
- Journal of Chongqing Medical University Issue 2, Pages: 302-304(2005)
- 作者机构：
  
  1. 重庆医科大学第二临床学院血液科
  2. 重庆医科大学第二临床学院血液科,重庆,400010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.02.040
  CLC： R733
- Published：2005，
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[1]娄世锋,陈林,陈姝,周慷,罗云,邓建川.两次输注自体干细胞移植治疗血液肿瘤4例报告[J].重庆医科大学学报,2005(02):302-304.

LOU Shifeng, et al. Autologous peripheral blood stem cell transplantation with tandem transfusion of stem cells in treating hematological malignant disease-A report of 4 cases. [J]. Journal of Chongqing Medical University (2):302-304(2005)
[1]娄世锋,陈林,陈姝,周慷,罗云,邓建川.两次输注自体干细胞移植治疗血液肿瘤4例报告[J].重庆医科大学学报,2005(02):302-304. DOI： 10.13406/j.cnki.cyxb.2005.02.040.

LOU Shifeng, et al. Autologous peripheral blood stem cell transplantation with tandem transfusion of stem cells in treating hematological malignant disease-A report of 4 cases. [J]. Journal of Chongqing Medical University (2):302-304(2005) DOI： 10.13406/j.cnki.cyxb.2005.02.040.

摘要

目的:观察两次干细胞输注在自体外周血干细胞移植（APBSCT）中对中性粒细胞及血小板减少的影响

观察其对患者并发感染和出血的影响。方法:对4例血液肿瘤患者经化疗+G -CSF动员并采集外周血干细胞

预处理后分别于0、+ 3天回输外周血干细胞采集物

观察外周血ANC、BPC及移植相关并发症和血液制品支持治疗情况。结果:用Cy +AraC +G -CSF动员可获足够CD34+细胞

患者ANC低于0 .5×10 9/L为5～12天

BPC持续低于2 0×10 9/L仅为3～4天

仅1例因输血小板发热

仅1例因口腔出血点输血小板1单位

移植费用降低。结论:两次干细胞输注在自体干细胞移植中可缩短粒细胞及血小板减少时间

并减少感染和出血

降低支持治疗费用

Abstract

Objective:To observe the effect of autologous peripheral blood stem cells transplantation (APBSCT) on neutropenia and thrombocytopenia when tandem transfusion of stem cells is given.Methods:4 patients with hematological disease were mobilized with Cy+AraC+G-CSF before peripheral blood stem cells(PBSC) were collected.Peripheral blood stem cells transfusion were on 0 day and 3rd day after conditioning regimens.Results:The sufficient number of CD34+ cells could be collected.Neutropenia lasted 5-12days

while severe thrombocytopenia(BPC≤20×10 9/L)lasted only 3-4 days.Conclusion:APBSCT with tandem transfusion of stem cells result in shortening period of neutropenia and thrombocytopenia

less occurrence of neutropenic fever and severe bleeding

and reduction of cost.

关键词

自体外周血干细胞移植淋巴瘤多发性骨髓瘤

Keywords

Autologous peripheral blood stem cells transplantation(APBSCT)lymphomamultiple myeloma

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