Clinical comparative study of simvastatin, xuezhikang and pravastatin in common doses on primary hyperlipidemia

LI Lihua; et al

doi:10.13406/j.cnki.cyxb.2005.02.033

您当前的位置：

首页 >

文章列表页 >

Clinical comparative study of simvastatin, xuezhikang and pravastatin in common doses on primary hyperlipidemia

更新时间：2024-01-17

- Clinical comparative study of simvastatin, xuezhikang and pravastatin in common doses on primary hyperlipidemia
- Journal of Chongqing Medical University Issue 2, Pages: 278-281(2005)
- 作者机构：
  
  1. 重庆医科大学临床学院心内科
  2. 重庆医科大学临床学院心内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.02.033
  CLC： R589.2
- Published：2005，
扫描看全文
[1]李骊华,邓国兰,陈运贞.临床常用剂量下的舒降之、血脂康、美百乐镇对原发性高脂血症调脂作用的比较[J].重庆医科大学学报,2005(02):278-281+284.

LI Lihua, et al. Clinical comparative study of simvastatin, xuezhikang and pravastatin in common doses on primary hyperlipidemia. [J]. Journal of Chongqing Medical University (2):278-281(2005)
[1]李骊华,邓国兰,陈运贞.临床常用剂量下的舒降之、血脂康、美百乐镇对原发性高脂血症调脂作用的比较[J].重庆医科大学学报,2005(02):278-281+284. DOI： 10.13406/j.cnki.cyxb.2005.02.033.

LI Lihua, et al. Clinical comparative study of simvastatin, xuezhikang and pravastatin in common doses on primary hyperlipidemia. [J]. Journal of Chongqing Medical University (2):278-281(2005) DOI： 10.13406/j.cnki.cyxb.2005.02.033.

摘要

目的:验证舒降之、血脂康、美百乐镇的调脂作用并做比较研究。方法:6 0例高脂血症患者随机分为3组

舒降之2 0mg每晚顿服;美百乐镇10mg每晚顿服;血脂康0 .6 g早晚各1次口服;服药前及服药后4、8、12周测定血脂。结果:舒降之组治疗后4周TC、LDL -C有下降（P <0 .0 5 ）

12周比4周下降更明显（P <0 .0 5 ）。美百乐镇组治疗后4周TC、LDL -C有下降（P <0 .0 5 ）

12周与4周无明显变化（P >0 .0 5 ）。两组的TG、HDL -C治疗前后均无明显变化（P >0 .0 5 ）。血脂康组治疗后4周TC、LDL -C、TG有下降（P <0 .0 5 ）

TC、LDL -C 12周比4周下降更明显（P <0 .0 5 ） ;HDL治疗前后无明显变化（P>0 .0 5 ）。舒降之组治疗后8周、12周LDL -C分别下降（ 4 0 %

4 5 % ）

明显大于血脂康组（ 31%与36 % ）和美百乐镇组（ 31%与35 % ）（P <0 .0 5 ）。血脂康组治疗后8周、12周TG分别下降（ 33%

35 % ）

明显大于舒降之组（ 2 5 %

2 6 % ）和美百乐镇组（ 18%

19% ）（P <0 .0 5 ）。3组TC、TG、HDL -C总有效率无显著差异（P >0 .0 5 ）。结论:舒降之、血脂康、美百乐镇降脂疗效确切

但3种药疗效判断及调整治疗的时间窗不同。舒降之降LDL -C能力强

血脂康降TG能力强且较经济实用

Abstract

Objective:To compare the effects of simvastatin

xuezhikang and pravastatin in patients with primary hyperlipidemia.Methods:Sixty patients were randomly divided into three groups

simvastatin 20mg were taken once a day at night;provastatin 10mg were taken once a day at night;xuezhikang 0.6g were taken twice a day in the morning and at night.Blood samples were taken before and 4 weeks

8 weeks

12 weeks after the treatment.Results:In simvastatin group:the serum levels of total cholesterol(TC)

low-density lipoprotein cholesterol(LDL C) decreased markedly at the end of 4 weeks compared with those of the baseline ( P <0.05).Significant differences in TC

LDL C were found between the end of 4 weeks and 12 weeks ( P <0.05).In pravastatin group:there is a noticeable drop in TC

LDL C at the end of 4 weeks

but no further obvious drop between 4 weeks and 12 weeks.Concentrations of TG and HDL C were not changed obviously in both groups after 12 weeks of treatment compared with the baseline ( P >0.05).In xuezhikang group:after 4 weeks of treatment

LDL C reduced markedly( P <0.05).Further significant lowering of TC

LDL C were noted after 12 weeks as compared with 4 weeks ( P <0.05).Only HDL C was not changed after the treatment in contrast with the baseline ( P >0.05).From the change rates

we can see after 8 weeks

12 weeks of treatment the level of LDL C drcreased more significantly in simvastatin group (40%

45%) than in xuezhikang (31%

36%) and provastatin (31%

35%) ( P <0.05);however

the level of TG lowered more obviously in xuezhikang group (33%

35%) than in simvastatin(25%

26%) and provastatin (18%

19%)( P <0.05).At the end of 12 weeks

the total effective rates of decreasing TC

HDL C have no significance among three groups ( P >0.05).Conclusion:The clinical effects of simvastatin

xunzhikang

provastatin on primary hyperlipidemia were equal among the three groups

but the time is different about when they take great effects respectively.Next

LDL C lowering effect of simvastatin was significant.Finally

xuezhikang was the best in reducing TG among the three groups and it has a relatively good economic effectiveness.

关键词

高脂血症舒降之血脂康美百乐镇

Keywords

hyperlipidemiaSimvastatinXuezhikangProvastatin

references

Views

115

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Preliminary study on the potential molecular net work interaction of ferroptosis in liver transcriptome of ApoE^-/-hyperlipidemic mice

Changes of rats ovarian granular cells under high-fat fed state

Relationship between serum uric acid level and hyperlipidemia

Experimental study on lipid regulation function of the Xi-zhi-jiang Capsule

Epidemiological survey on fatty liver among enterprise staff in ethnic minorities’ regions in Guangxi

Related Author

Wenna Chen

Xin Zhang

Hu Xiaojing

Wang Lianlian

Li Cong

陈运贞

雷寒

马康华

Related Institution

Postgraduate School, Liaoning University of Traditional Chinese Medicine

Teaching and Research Center, Liaoning University of Traditional Chinese Medicine

Department of Obstetrics and Gynecology,The First Affiliated Hospital of Chongqing Medical University

Cardiology Division,College of Clinical Medicine,Chongqing Medical University

Department of Traditional Chinese Medicine,Chongqing Medical University

⁰