Correlation study on matrix metalloproteinase-3 and tumors in children

HUA Yi; et al

doi:10.13406/j.cnki.cyxb.2005.02.028

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Correlation study on matrix metalloproteinase-3 and tumors in children

更新时间：2024-01-17

- Correlation study on matrix metalloproteinase-3 and tumors in children
- Journal of Chongqing Medical University Issue 2, Pages: 263-265(2005)
- 作者机构：
  
  1. 重庆医科大学儿科学院泌尿外科
  2. 重庆医科大学儿科学院泌尿外科,重庆,400014
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.02.028
  CLC： R730.2
- Published：2005，
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[1]华燚,魏光辉.基质金属蛋白酶-3与儿童常见实体肿瘤的相关性[J].重庆医科大学学报,2005(02):263-265.

HUA Yi, et al. Correlation study on matrix metalloproteinase-3 and tumors in children. [J]. Journal of Chongqing Medical University (2):263-265(2005)
[1]华燚,魏光辉.基质金属蛋白酶-3与儿童常见实体肿瘤的相关性[J].重庆医科大学学报,2005(02):263-265. DOI： 10.13406/j.cnki.cyxb.2005.02.028.

HUA Yi, et al. Correlation study on matrix metalloproteinase-3 and tumors in children. [J]. Journal of Chongqing Medical University (2):263-265(2005) DOI： 10.13406/j.cnki.cyxb.2005.02.028.

摘要

目的:探讨儿童肿瘤组织中基质金属蛋白酶（MMPs）的表达与肿瘤恶性程度、浸润转移的相关性。方法:采用免疫组织化学SABC法测定MMP - 3在各儿童常见肿瘤组织中表达的强度。结果:MMP - 3的表达强度在恶性肿瘤转移组、恶性肿瘤未转移组、良性肿瘤组之间均存在统计学差异（P <0 .0 5 ）。结论:在儿童常见实体肿瘤中

MMP - 3表达与肿瘤恶性程度相关

MMP - 3表达越强

肿瘤恶性程度越高

浸润转移可能性也越大。提示MMP - 3可作为预测儿童实体瘤转移与预后的一个临床指标

Abstract

Objective:To study the relationship between MMPs and the metastasis and the malignant degree of tumors in children.Methods:The expression of MMPs in different tumor groups was measured by means of immuno-histochemistry.Results:The expressions of MMP-3 in cytoplasm of tumor cells were observed.There was significant difference( P <0.05) among the groups.Conclusion:In solid tumors of children

the expression of MMP-3 has close relationship with degree of malignancy.The stronger the expression of MMP-3 is

the higher the degree of malignancy is and the more probable the metastasis.It suggests that MMP-3 could be a marker to forecast the metastasis of tumors and to estimate the prognosis of tumors.

关键词

基质金属蛋白酶肿瘤转移儿童

Keywords

MMPstumormetastasischildren

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Related Institution

Key Laboratory of Molecular Biology of Infectious Diseases，Ministry of Education，Chongqing Medical University

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Department of Respiratory and Critical Care Medicine,General Hospital of Ningxia Medical University

Department of Clinical Molecular Medicine of Children’s Hospital of Chongqing Medical University， National Clinical Research Center for Child Health and Disorders，Ministry of Education Key Laboratory of Child Development and Disorders，Chongqing Key Laboratory of Pediatrics

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