Relationship between VacA genotypes of Helicobacter pylori and gastric diseases

TIAN Yiling; et al

doi:10.13406/j.cnki.cyxb.2005.02.025

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Relationship between VacA genotypes of Helicobacter pylori and gastric diseases

更新时间：2024-01-17

- Relationship between VacA genotypes of Helicobacter pylori and gastric diseases
- Journal of Chongqing Medical University Issue 2, Pages: 253-255(2005)
- 作者机构：
  
  1. 重庆医科大学基础医学院微生物学教研室
  2. 重庆医科大学基础医学院卫生科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2005.02.025
  CLC： R573
- Published：2005，
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[1]田一玲,杨致邦,余歌军.幽门螺杆菌VacA基因型与胃疾病[J].重庆医科大学学报,2005(02):253-255.

TIAN Yiling, et al. Relationship between VacA genotypes of Helicobacter pylori and gastric diseases. [J]. Journal of Chongqing Medical University (2):253-255(2005)
[1]田一玲,杨致邦,余歌军.幽门螺杆菌VacA基因型与胃疾病[J].重庆医科大学学报,2005(02):253-255. DOI： 10.13406/j.cnki.cyxb.2005.02.025.

TIAN Yiling, et al. Relationship between VacA genotypes of Helicobacter pylori and gastric diseases. [J]. Journal of Chongqing Medical University (2):253-255(2005) DOI： 10.13406/j.cnki.cyxb.2005.02.025.

摘要

目的:探讨幽门螺杆菌（H .pylori）VacA基因型在各种胃肠疾病中的分布及关系。方法:从胃十二指肠疾病患者胃粘膜标本中分离培养H .pylori

PCR测定VacA基因型。结果:10 8株H .pylori菌株

VacAs1a阳性为85株（ 79% ）

VacAs1b阳性2 2株（ 2 0 % ）

VacAm1阳性2 9株（ 2 7% ）

VacAm2阳性77株（ 71% ）

VacAs1a/m2阳性6 6株（ 6 1.1% ）

未发现s2型菌株。其中

慢性胃炎患者VacAs1a阳性率为6 5 .4 % （ 34/ 5 2 ）

消化性溃疡患者VacAs1a阳性率为90 % （ 36 / 4 0 ）

胃癌患者VacAs1a阳性率为94 % （ 15 / 16 ）。结论:H .pylori菌株VacA基因型绝大多数为s1a/m2型

该型菌株存在于各种胃肠疾病中

无s2型

Abstract

Objective:To investigate the distribution of Helicobacter pylori (H.pylori) VacA genotypes in different gastrointestinal diseases and the relationship among each other.Methods:VacA genotypes of 108 H.pylori strains isolated from patients with chronic gastritis

peptic ulcer and gastric cancer were tested by polymerase chain reaction (PCR).Results:The frequencies of the signal allele sla

slb and the middle-region allele m1

m2 were 85 (79%)

22 (20%)

29 (27%)

77 (71%) respectively.The numbers of H.pylori strains of VacA s1a/m2 positive were 66 (61.1%).The s2 form was not found.The positive rates of VacA s la of H.pylori strains isolated from patients with chronic gastritis

peptic ulcer and gastric cancer were 65.4% (34/52)

90% (36/40) and 94% (15/16) respectively.Conclusion:The majority of H.pylori strains isolated from Chongqing patients express s1a/m2.The s1a/m2 genotype is dispersed in all of the gastrointestinal diseases associated with H.pylori.However the s2 form is not found.

关键词

幽门螺杆菌细胞空泡毒素基因聚合酶链反应胃肠疾病

Keywords

Helicobacter pyloriVacuolating cytotoxin genePCRGastrointestinal diseases

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